摘要
目的检测Hsp70在视网膜母细胞瘤和正常视网膜组织中的表达,并讨论其意义。方法利用组织芯片,采用免疫组化SA法检测视网膜母细胞瘤和正常视网膜组织中Hsp70的表达。结果视网膜母细胞瘤组织芯片中Hsp70在胞浆有高表达(13/16),在正常视网膜组织中表达阳性率低(1/5),二者间存在显著性差异(P=0.0254<0.05)。结论Hsp70在视网膜母细胞瘤中高表达,它可能参与了视网膜母细胞瘤的发病。
Objective To detect the expression of Hsp70 in tissue microarmy of retinoblastoma and normal retina, to evaluate it＇ s clinical significance.Methods Tissue microarray of retinoblastoma and normal retina tissues were analyzed by S-A immunohistochemical staining for Hsp70 expression. Hsp70 was over expressed in cytoplasm in cancer tissue （13/16）, while it was hardly seen in normal retinal tissues（1/5）. There were significant difference in the positive rate of Hsp70 between the cancer tissue and the normal retinal tissues（P = 0.025 4 〈 0.05）. Conclusion There is over expression of Hsp70 in retinoblastoma, which suggests that it may be related to the development of rctlnoblastoma. [Rec Adv Ophthalmol 2006;26（7） ：514-516]
出处
《眼科新进展》
CAS
2006年第7期514-516,共3页
Recent Advances in Ophthalmology
