摘要
研究糠秕孢子菌对培养角质形成细胞表达 p53,p21,p185的影响。结果发现糠秕孢子菌能刺激角质形成细胞表达 p53,p185的含量增加。与对照组相比均有显著差异。但 p21的表达量与对照组相比，却明显减少，统计学处理有显著性差异。表明糠秕孢子菌与角质形成细胞共同培养可以促使角质形成细胞的增殖及分化。
The expression of p53,p185,p21 was detected by using ABC immunohistochemical stain. In the experimental groups, the percentages of p53, p185 positive keratinocytes were statistically higher than those of the controls. But, the percentage of p21 positive keratinocytes was statistically lower than that of the controls. The results showed that the expression of p53, p185 was up-regulated and the expression of p21 was down-regulated by P.orbiculare. It seems that P.orbiculare could promote proliferation and differentiation of keratinocytes.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2001年第1期7-9,共3页
Journal of Clinical Dermatology
基金
P&G公司资助课题
