摘要
目的 探讨铝对大鼠学习记忆的影响及海马 CA3区突触界面结构的变化。方法 采用电迷宫测试行为学反应 ,采用电镜技术及体视学方法研究突触界面结构。结果 实验组通过迷宫时间显著延长 (P <0 .0 1) ,同时伴随突触丢失 ,突触后膜致密物质变薄 (P <0 .0 1) ,细胞器有病理性改变。结论 铝可致学习记忆功能障碍 。
Objective To study the effect of aluminum on learning and memory and the synaptic interface constructure in hippocampus CA 3 area in rats. Methods The electrical maze were used to test the behavioral reaction of rats. Some parameters of synaptic interface structure were measured by the method of ultrastructural quantitative analysis in hippocampus CA 3 area in the rats. Results The time coming through the E maze prolonged siginificantly in the experimental group compared with the normal control (P<0 01), meanwhile the cyto apparatus demonstrated the pathogenetic changes. Amounts of synapse obviously reduced and the post synaptic density turned thinner in experimental group than in the control group (P<0 01). Conclusion Aluminum can cause the malfunction on learning and memory, which related to the plastic of synapse.
出处
《解剖科学进展》
CAS
2001年第1期4-6,共3页
Progress of Anatomical Sciences
