摘要
目的 探讨寻常性银屑病患者外周血单一核细胞（ＰＢＭＣｓ）产生白介素２（ＩＬ－２）及白介素４（ＩＬ－４）的能力与病程演变的关系。方法 用生物活性法检测产生ＩＬ－２、双抗体夹心ＥＬＩＳＡ法检测产生ＩＬ－４的水平。结果与１２例健康人比较，患者组ＩＬ－２低于对照组（Ｐ＜０．０１），静止期组较进行期组降低更明显；患者组ＩＬ－４低于对照组（Ｐ＜０．０５），进行期组明显低于对照组（Ｐ＜０．０１），而静止期组与对照组比较差异无显著性（Ｐ＞０．０５）。结论患者从进行期向静止期演变可能与ＰＢＭＣｓ产生ＩＬ－２及ＩＬ－４的能力改变有关。
Objective To study the correlation between the clinical evolution and the mitogen-stimulated production of in- terleukin-2(IL-2) and interleukin-4(IL-4) in vitro of peripheral blood mononuclear cells(PBMCs) in patients with psoriasis vul- garis. Methods The production of IL-2 was analyzed with bicactivity assay. The production of IL-4 was assayed by enzyme- linked immunosorbent assay(ELISA) test. For comparison, PBMCs from 12 healthy controls were tested equally. Results The IL-2 production of patients with psoriasis was more decreased than these of the healthy contrls(P < 0. 01 ), especially in patients with static psoriasis. The production of IL-4 was inhibited in patients with active psoriasis(P< 0. 01 ), while it became normal in patients with static psoriasis(P >0. 05). Conclusion There is a possible correlation between the clinical evolution of psoriasis and the production of IL-2 and IL-4 of PBMCs.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2001年第2期76-78,共3页
The Chinese Journal of Dermatovenereology
