摘要
目的 评价氟西汀和氯米帕明对难治性强迫症的疗效。方法 符合CCMD-2-R强迫症诊断标准的难治性病人共60例,随机分为两组,分别用氟西汀和氯米帕明系统治疗8周。采用耶鲁布朗强迫量表(Y-BOCS)和药物副反应量表(TESS)评价疗效及主要副反应。结果 两药的总体疗效相当;氟西汀对强迫性行为见效快,疗效好,副作用小,尤其是心血管系统及抗胆碱能副反应少,远期效果优于氯米帕明。结论氟西汀尤其适用于伴有心血管疾病而又以强迫行为为主的难治性强迫症病人。
Objective To compare the efficacy and side effects of fluoxetine with clomipramine in treating 60 refractory obsessive - compulsive patients. Methods 60 refractory obsessive - compulsive patients who meet the criteria of CC-MD - 2 - R were recruited for the 8 weeks double controlled trial comparing fluoxetine with clomipramine. Symptom improvement and side effects were monitored with clinical evaluation, Y - BOCS, and TESS. Results The efficacy was better in the fluoxetine group than that in clomipramine group at the end of 2 weeks, the efficacy was good in both trial group at the end of 8 weeks, and there was no difference between two groups (P > 0.05). There was less side effects in fluoxetine group than that in clomipramine group. Conclusion In the treatment of refractory obsessive - compulsive patients, the efficacy of fluoxetine was better than that of clomipramine, and the former was more suitable for the patients with circulatory disorders.
出处
《山东精神医学》
2001年第1期46-49,共4页
Shangdong Archives of Psychiatry
关键词
氟西汀
氯米帕明
难治性强迫症
治疗
Obsessive - Compulsive neurosis Fluoxetine Clomipramine
