摘要
目的探讨帕罗西汀对强迫症的临床疗效及副反应。方法对４２例强迫症患者应用帕罗西汀（１５例）与氯丙咪嗪（１５例）、安慰剂（１２例）进行对照治疗。采用ＹａｌｅＢｒｏｗｎ强迫量表（ＹＢＯＣＳ）、Ｍａｒｋｓ恐怖强迫量表（ＭＳＣＰＯＲ）、汉密尔顿抑郁量表（ＨＡＭＤ）、副反应量表和临床疗效评定标准，分别评定疗效和副反应。结果帕罗西汀组与氯丙咪嗪组疗效近似（Ｐ＞０．０５），帕罗西汀组与氯丙咪嗪组的显效率（痊愈＋显著进步）差异无显著性（χ２＝０．１４，Ｐ＞０．０５），均明显优于安慰剂组（Ｐ＜０．０１）。各组治疗前后量表的评分显示，ＹＢＯＣＳ、ＭＳＣＰＯＲ、ＨＡＭＤ总分，帕罗西汀组和氯丙咪嗪组治疗后减分率均高于安慰剂组（Ｐ＜０．０１），前两组比较差异无显著性（Ｐ＞０．０５）。帕罗西汀组副反应较氯丙咪嗪组少且轻微。结论帕罗西汀与氯丙咪嗪对强迫症均有较好的疗效，但帕罗西汀具有日服剂量小、给药方法简便。
Objective The purpose of this study was to investigate the clinical efficacy and the side effects of paroxetine in the treatment of obsessive compulsive disorder (OCD). Methods 42 patients who met the Chinese Classification and Diagnostic Criteria for Mental Disorders, the Second Revised Edition (CCMD 2 R) for OCD were involved in this study. Paroxetine efficacy in treatment of OCD were assessed with Y BOCS, MSCPOR, and the side effects were evaluated with Treatment Emergent Symptom Scale (TESS) compared with clomipramine and placebo. Results The therapeutic efficacy in paroxetine group was similar to that in clomipramine ( P >0.05), both effects of paroxetine and clomipramine were better than that of placebo ( P <0.01). However the side effects of paroxetine were lighter than clomipramine. Conclusion The results indicate that both paroxetine and clomipramine is effective in the treatment of OCD, but paroxetine showed more advantages for its convenient administration and low daily dosage and the side effects of it were light.
出处
《中华精神科杂志》
CAS
CSCD
1998年第4期215-215,共1页
Chinese Journal of Psychiatry
