摘要
为开发乌索酸这一抗肝炎高效新药 ,进行了乌索酸急性、亚急性毒性实验。测得小鼠口服乌索酸LD5 0 为 8 33g/kg;腹腔注射乌索酸LD5 0 为 6 37mg/kg ;小鼠皮下一次注射乌索酸 3 5g/kg,72小时内无一动物死亡 ;大鼠口服乌索酸 0 5g/kg日× 30天 ,其体重、血象、心电图、肝、肾功能均无明显影响 ,重要脏器组织病检亦未见病理改变 ,结果表明乌索酸毒性较低。
In order to develope a new high effectivehepatitis-against medicine-Ursolic acid A result of experiment on acute and subacute poison of Ursolic acid isreported here when the mouse took medicine of Ursolic acid LD 50 by 8 33g/kg,took an injection of Ursolc acid LD 50 by 637mg/kg in the stomach,and took hypodermic injection onetime by 3 5g/kg We found no animals were dead with in 72 hours When the rat took medicine of Ursolic acid by 0 5g/kgper day for 30 days, we found that its weight, hemogram,electrocardiogram,the function of liver and kidney have no obvious change,and when the major organs were under the tissue pathological examination, we found there was no pathological change The result shows that Ursolic acid wasless poisonous [
出处
《宜春医专学报》
2001年第1期54-54,共1页
Journal of Yichun Medical College
