摘要
目的 :通过肿瘤抑制试验和对几个相关免疫指标的测定 ,探讨某复合胶囊对移植性肿瘤的抑制作用和可能的机理。方法 :小鼠移植性 Heps、S180瘤株抑制实验及荷瘤小鼠 NK细胞活性测定实验。结果 :该胶囊在 45 0、90 0和 2 70 0 mg/ kg .b.w.剂量下 ,对皮下移植的 Heps及 S180瘤株生长均有大于 30 %的抑瘤率 ,与阴性对照相比 ,差异有显著性或极显著性 (P<0 .0 5 ,P<0 .0 1)。相同剂量下该胶囊对小鼠单核 -巨噬细胞吞噬功能有增强作用 (P<0 .0 5 ) ,可增加 NK细胞活性 (P<0 .0 5 ) ,增强小鼠细胞免疫功能(P<0 .0 5 ,P<0 .0 1) ,增强小鼠的体液免疫功能 (P<0 .0 1)。结论 :该胶囊能全面提高机体的免疫机能 ,具有抑瘤作用。
Objective: The compound's tumor inhibition effect and its mechanism were studied with tumor inhibition test and determining related immune indexes. Methods and Results: When the doses were at 450,900 and 2700mg/kg.b.w. respectively , the growth of Heps and S180 by hypodermic transplantation was inhibited for more than 30%(the inhibitory tumor rate.). The difference is significant ( P <0.05, P <0.01), Similar results were observed from a repeat test. Under the same dosages, it was found that the function of monocyte-macrophage system of mice was augmented ( P <0.05), and also the activation of NK cells ( P <0.05).In one word ,the capsule can strengthen both function of the cell-mediated immunity ( P <0.05, P <0.01) and the humoral immunity ( P <0.01). Conclusion: The compound can suppress the growth of animal transplantative tumor by enhancing the immune function of the body.
出处
《江苏预防医学》
CAS
2001年第1期7-9,共3页
Jiangsu Journal of Preventive Medicine
关键词
绞股蓝
灵芝
胶囊
肿瘤抑制
免疫功能
移植性肿瘤
Gynostemma Pentaphy mak
magic fungus
capsule
tumor inhibition
immunity function
