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干扰素介导的抗肿瘤新生血管形成作用 被引量：4

The effect of interferon mediated antiangiogenesis on tumor therapy
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摘要 机体抗血管形成的主要因子之一是β-干扰素 (IFN -β)。经常 (或每日 )应用低剂量 IFN (α或β)或直接将 IFN-β基因转导到肿瘤细胞内 ,在一些临床前原位肿瘤模型中已经显示出显著的疗效。对干扰素抗血管形成作用的进一步认识 。
作者 曹传武 王杰军
机构地区 第二军医大学附属长征医院肿瘤科
出处 《国外医学（肿瘤学分册）》 2001年第1期14-17,共4页 Foreign Medical Sciences (Cancer Section)
关键词 干扰素 新生血管 抗血管形成
分类号 R730.2 [医药卫生—肿瘤]
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参考文献10

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  • 3Dong Z,Greene G,Pettaway C,et al.Suppression of angiogenesis, tumorigenicity, and metastasis by human prostate cancer cells engineered to produce interferon beta[].Cancer Research.1999
  • 4White CW,Sondheimer HM,Crouch EC,et al.Treatment of pulmonary hemangiomatosis with recombinant interferon alfa-2a[].The New England Journal of Medicine.1989
  • 5Dinney CP,Bielenberg DR,Reich R,et al.Inhibition of basic fibroblast growth factor expression, angiogenesis, and growth of human bladder carcinoma in mice by systemic interferon-alpha administration[].Cancer Research.1998
  • 6Singh RK,Gutman M,Bucana CD,et al.Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas[].Proceedings of the National Academy of Sciences of the United States of America.1995
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  • 8Negrier S,Escudier B,Lasset C,et al.Recombinant human interleukin-2, recombinant human interferon alfa-2a, or both in metastatic renal-cell carcinoma[].The New England Journal of Medicine.1998
  • 9Hong YK,Chung DS,Joe YA,et al.Efficient inhibition of in vivo human malignant glioma growth and angiogenesis by interferon-beta treatment at early stage of tumor development[].Clinical Cancer Research.2000
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同被引文献33

  • 1孙春艳,胡豫,吴涛,王雅丹,何文娟.多发性骨髓瘤细胞脑源性神经营养因子对血管新生作用的研究[J].中华血液学杂志,2005,26(10):602-606. 被引量：13
  • 2Aguayo A, Kantarjian H, Manshouri T, et al. Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes. Blood, 2000 ;96 ( 6 ) :2240 - 2245.
  • 3Livak K J, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2^-△△cT method. Methods, 2001 ;25:402-408.
  • 4Verstosck S, Kantarjian H, Manshoufi T, et al. Progonostic significance of ceUeular vascular endothelial growth factor expression in chronic phase chronic myeloid leukemia. Blood, 2002 ;99 (6) : 2265 - 2267.
  • 5Xiao Z, Wang Y, Lu L, et al. Anti-angiogenesis effects of meisoindigo on chronic myelogenous leukemia in vitro. Leuk Res. 2006;30( 1 ) :54 -59.
  • 6Di Raimondo F, Palumbo GA, Molica S, et al. Acta Haematol, 2001 ; 106(4) : 177 - 183.
  • 7Wang L, Tang ZY, Qin LX, et al. High-dose and long-term therapy with interferon-alfa inhibits turner growth and recurrence in nude mice bearing human hepatocellular carcinoma xenografts with high metastatic potenial. Hepatology, 2000 ;32 ( 1 ) :43 - 48.
  • 8Wu WZ, Sun HC, Shen YF, et al. Interferon alpha 2a down- regulating VEGF expression through P13 kinase and MAP kinase signaling pathways. J Cancer Res Clin Oncol, 2005 ; 131 ( 3 ) : 169 - 178.
  • 9汤地,梁力建,彭宝岗,周凡,李绍强,殷晓煜.IFN-α抑制HUVECs以及荷人肝癌裸小鼠血管生成的实验研究[J].中国病理生理杂志,2007,23(8):1495-1498. 被引量：6
  • 10司徒镇强 吴军正.细胞培养[M].西安:世界图书出版公司,2004.239-245.

引证文献4

二级引证文献9

国外医学（肿瘤学分册）
2001年 第1期

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