摘要
采用斑点酶标染色技术对临床疑似恙虫病患者196份血清进行了IgM抗体的检测并作了初步统计分析。总检出率为92.3%;病后3天内检出率为50%,抗体滴度几何平均值(GMT)为226;4～7天检出率为83%,GMT为320;第4周抗体滴度达峰值,GMT为1585,检出率为100%。同时在4周内其GMT与发病时间呈正相关。提示应用本法进行IgM抗体的检测对恙虫病的早期诊断和流行病学调查有着重要意义。
196 sera from patients with scrub typhus were detected for IgM by microimmunoper-oxidase labelling staining method. The total positivity rate was 92.3. The initial IgM response generally appeared by 3 days after onset of illness. The geometric mean antibody titer (GMT) of the antibody was 1:226. The positivity rate of 4-7 days after onset of illness was 83% and GMT 1:320. The peak value of IgM was in 4th week, with 1:1558 GMT and 100% positivity rate. The analysis of results demonstrated that the titer of IgM was in proportion to the days after onset of illness during the period of 0-4 weeks. These results suggested that the detection of the specific IgM level by this method may play an important role in clinical diagnosis of acute stage and epidemiological survey of scrub typhus.
出处
《军事医学科学院院刊》
CSCD
北大核心
1992年第4期248-250,共3页
Bulletin of the Academy of Military Medical Sciences
关键词
恙虫病
免疫球蛋白G
抗体
IgM
scrub typhus
microimmunoperoxidase labelling staining
geometric mean antibody titer
