摘要
采用Ｂｏｒｎ法、ＥＬＩＳＡ法、放射免疫分析法和电镜对３８例慢性重型肝炎（慢重肝）患者血小板功能、调节介质和超微结构进行了系列研究。结果发现：血浆β－血小板球蛋白（β－ＴＧ）显著升高，血小板聚集率（ＰＡＲ）、血小板ＴＸＢ２及ｃＡＭＰ含量明显降低；ＰＡＲ与血小板ＴＸＢ２及ｃＡＭＰ、ＴＸＢ２与ｃＡＭＰ之间均呈非常显著相关，血浆β－ＴＧ与ＰＡＲ及ｃＡＭＰ之间呈非常显著负相关；超微结构以血小板活化和退行性变为突出改变。分析认为慢重肝患者可能因体内各种因素作用，使血小板发生持续性激活，引起获得性血小板贮存池病。
Born’s method, ELISA,radioimmunoassy and electron microscopy were employed toobserve the function,regulatory mediators and ultrastructure of platelets in 38 patientswith chronic severe viral hepatitis(CSVH). The results showed that plasma β-thrombo-globulin(β-TG) increased markedly,while platelet aggregation ratio(PAR)、plateletTXB2 and cAMP reduced significantly.The changes of plasma β-TG were in negativecorrelation with those of PAR and cAMP, PAR were in positive correlation with plate-lets TXB2 and cAMP, positive correlation were also found between TXB2 and cAMP.The outstanding ultrastructural changes of platelets were activation and degeneration.The authors considered that under the influences of various factors,in CSVH patientsthe platelets may be activated persistently, and finally induce acquired storage pooldisease of platelets.
出处
《中华传染病杂志》
CAS
CSCD
北大核心
1995年第3期137-140,共4页
Chinese Journal of Infectious Diseases
关键词
病毒性肝炎
血小板功能
调节介质
超微结构
Chronic severe viral hepatitis
Platelet function
Regulatory mediators
Ultrastructure
