摘要
目的 通过增殖相关抗原Ki 6 7的检测 ,观察其与非霍奇金淋巴瘤 (NHL)恶性程度和预后的关系。方法 用免疫组织化学染色的方法 ,对 34例NHL活检石蜡组织进行Ki 6 7检测 ,观察Ki 6 7指数 (Ki 6 7LI)与NHL恶性程度、化疗疗效和生存期的关系。结果 NHL低度恶性 (LG)、中度恶性 (MG)和高度恶性 (HG)三组之间Ki 6 7LI均有显著性差异 (P <0 0 0 1) ,恶性程度低的 ,Ki 6 7LI低 ;恶性程度高的 ,Ki 6 7LI高。首次化疗缓解与未缓解组之间Ki 6 7LI无显著性差异 (P >0 1)。Ki 6 7LI≤ 2 0 %组的生存期较Ki 6 7LI >2 0 %组为长 (P <0 0 5 )。结论 增殖相关抗原Ki 6 7的检测 ,能反映NHL肿瘤细胞的增殖活性 ,与NHL的恶性程度和预后密切相关 ,是判断NHL预后的有效指标。
Objective To evaluate the expression of proliferative antigen Ki 67 in patients with non Hodgkin’s lymphomas(NHL)for the purpose of studying relationship between the cell proliferation activity and the prognosis.Methods The labeling index of KI 67(Ki 67LI) was measured by immunohistochemistry on paraffin specimens in 34 cases of NHL.Results There were significant differences in the Ki 67LI among three groups( P< 0 001).The Ki 67LI was well related with the malignant grade of non Hodgkin’s lymphoma.It was shown that the level of Ki 67 in low grade group was lower than that in high grade group.There was no significant difference in Ki 67LI between remission and non remission groups after its first chemotherapy.The survival time was longer in Ki 67≤20% than in Ki 67>20% group.Conclusions Ki 67LI was positively related with the malignant grade and prognosis of non Hodgkin’s lymphomas.It was a favourable marker for prognosis.
出处
《江苏医药》
CAS
CSCD
北大核心
2001年第4期261-262,共2页
Jiangsu Medical Journal
