摘要
目的:研究抗病毒治疗对原发性肝癌的慢性乙型肝炎相关危险因素的干预作用。方法:回顾性分析青岛市传染病医院2010年2月至2012年6月住院的原发性肝癌患者病例249例,经统一编制的调查表记录相关数据,分析比较抗病毒治疗组与无抗病毒治疗组两组间各因素的分布差异。结果:抗病毒治疗组与无抗病毒治疗组患者被诊断为HCC前的HBV感染时间、肝硬化史以及HBV DNA载量,P<0.05,差异均有统计学意义;两组间的HBV感染模式、AFP、CEA差异无统计学意义;相关肝功能指标经统计学处理差异均有意义。结论:抗病毒治疗可以明显降低慢乙肝相关致癌因素在患者中的分布,有效抑制HBV DNA复制,进而或可降低乙肝相关性肝癌的发病率。
Objective： To investigate the intervention of antiviral therapy on the risk factors of chronic hepatitis B-related hepatoc- ellular carcinoma. Methods： 249 hospitalized cases of hepatocellular carcinoma in Qingdao Infectious Diseases Hospital from February 2010 to June 2012 were retrospectively analyzed. The relevant data recorded on the questionnaire prepared by the unified was used to compare the distribution of various factors between antiviral treatment group and no-antiviral treatment group. Results： The differences of time of HBV infection and that of cirrhosis before diagnosed with HCC, and HBV DNA level between antiviral treatment group and no-antiviral treatment group were statistically significant, P〈0.05; HBV infection patterns, AFP, CEA had no significant differences between the two groups. Differences of related indicators of liver function were statistically significant. Conclusions： Antiviral therapy could significantly reduce the percentage of the carcinogenic factors associated with chronic hepatitis B in patients, and it can effectively inhibit the replication of HBV DNA, which maybe reduce the incidence of HBV-related HCC.
出处
《现代生物医学进展》
CAS
2014年第20期3909-3917,共9页
Progress in Modern Biomedicine
关键词
原发性肝癌
慢性乙型肝炎
危险因素
抗病毒治疗
Hepatocellular carcinoma
Chronic hepatitis B
Risk factors
Antiviral therapy
