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环氧化酶抑制剂在防治阿片类药物诱发的术后痛觉过敏中的作用 被引量：4

Roles of cyclooxygenase inhibitors in the prevention and treatment of opioid-induced postoperative hyperalgesia
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摘要 背景 使用阿片类药物停药后,可导致患者疼痛敏感性增加,即阿片类药物诱发的痛觉过敏（opioid-induced hyperalgesia,OIH）,参与术后疼痛的组成.环氧化酶（cyclooxygenase,COX）抑制剂具有抗炎及抗痛觉过敏的作用,广泛用于术后镇痛治疗. 目的 了解COX抑制剂在防治OIH中的作用并进行归纳总结. 内容 COX抑制剂预防OIH的基础及临床研究现状. 趋向 COX抑制剂特别是COX-2抑制剂可有效减轻OIH,其作用机制还需进一步研究. Background Opioid-induced hyperalgesia （OIH） is defined as a state of nociceptive sensitization caused by exposure to opioids,which partially contributes to the postoperative pain. Cyclooxygenase （COX） inhibitors are widely used medications for postoperative pain control in clinic due to their anti-inflammatory and anti-hyperalgesia properties. Objective To review and summarize the roles of COX inhibitors in the prevention and treatment of OIH. Content This article reviews the latest basic and clinical research of COX inhibitors in the prevention and treatment of OIH. Trend COX inhibitors, especially COX-2 inhibitors can significantly attenuate OIH. However, further research is needed to dissect the mechanism of COX inhibitors in attenuating OIH.
作者 张婧 李乐 张粒子 姜珊 徐世元
机构地区 南方医科大学珠江医院麻醉科
出处 《国际麻醉学与复苏杂志》 CAS 2014年第6期559-561,I0001,共4页 International Journal of Anesthesiology and Resuscitation
关键词 环氧化酶 阿片类药物 痛觉过敏 Cyclooxygenase Opioid Hyperalgesia
分类号 R614 [医药卫生—麻醉学]
  • 相关文献

参考文献22

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共引文献66

同被引文献30

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引证文献4

二级引证文献26

国际麻醉学与复苏杂志
2014年 第6期

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