摘要
麻醉药物氯胺酮的单一异构体艾氯胺酮已作为抗抑郁药物上市,其不对称合成研究是近年来合成化学家研究的热点。本文总结了不对称重排、不对称胺化和烯烃不对称双官能团化3种合成艾氯胺酮的策略,为从事艾氯胺酮不对称合成的研究者提供参考。
Esketamine,a single isomer of the anesthetic drug ketamine,has been marketed as an antidepressant.Its asymmetric synthesis has become a research focus for synthetic chemists in recent years.In this review,three strategies including asymmetric rearrangement,asymmetric amination and asymmetric difunctionalization of alkene for the synthesis of esketamine have been summarized,which will be benefit to the researchers engaged in asymmetric synthesis of esketamine.
作者
郭明清
廖宗权
石莹
陈永盛
周海峰
GUO Mingqing;LIAO Zongquan;SHI Ying;CHEN Yongsheng;ZHOU Haifeng(Hubei Key Lab.of Natural Products Research&Development,College of Biological&Pharmaceutical Sciences,China Three Gorges University,Yichang 443002;Yichang Humanwell Pharmaceutical Co.,Ltd.,Yichang 443002)
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2021年第2期163-169,共7页
Chinese Journal of Pharmaceuticals
关键词
艾氯胺酮
去甲氯胺酮
麻醉药物
抗抑郁药
不对称合成
esketamine
norketamine
anesthetic drug
antidepressive drug
asymmetric synthesis
