摘要
试验发现KMnO4可氧化L-cys包覆ZnCdSe量子点产生强烈的化学发光现象，而头孢羟氨苄对该体系的化学发光具有很强的抑制作用，基于此，首次建立了头孢羟氨苄的流动注射化学发光抑制分析法。结果表明，发光信号的降低值ΔΙ与头孢羟氨苄的浓度在2.1×10-9～1.6×10-5 g／mL的范围内呈良好的线性关系，检出限为1.7×10-9 g／mL。对1×10-5 g／mL 头孢羟氨苄测定的相对标准偏差为1.89％（n＝11），加标回收率在95％～103％之间。本方法快捷、简便且具有很高的灵敏度，可用于头孢羟氨苄的测定，结果满意。
A new flow injection chemiluminescence method for the determination of the content of cefadroxil was described.It was found that KMnO 4 can oxidized L -cysteine capped ZnCdSe quantum -dots to produce strong chemiluminescence which can be inhibited by cefadroxil.On this basis , a flow injection procedure combined with inhibited chemiluminescence detection was developed for the determination of the cefadroxil .The method was fast , simple and sensitive.The detection limit was 1.7 ×10 -9 g/mL, the relative standard deviation was 1.89% （1.0 ×10 -5 g/mL protocatechuic acid , n=11 ）.The linear range was 2.1 ×10 -9 -1.6 ×10 -5 g/mL.The method was applied to the determination of the content of cefadroxil.
出处
《广州化工》
CAS
2014年第12期136-138,共3页
GuangZhou Chemical Industry
