摘要
目的:探讨维族食管鳞癌病人癌细胞增殖、侵袭与幽门螺杆菌(Hp)感染的关系。方法:应用免疫组织化学法对164例新疆维族食管鳞状细胞癌组织标本进行Hp、Ki67和MMP2蛋白的检测。结果:164例食管鳞状细胞癌中Hp、Ki67和MMP2阳性率分别为81.7%(134/164)、67.1%(110/54)和86.6%(142/164)。食管鳞癌患者中Hp阳性组Ki67表达明显高于Hp阴性组,二者密切相关(rs=0.340,P<0.01);Hp阳性组MMP2表达明显高于Hp阴性组,二者密切相关(rs=0.739,P<0.01)。结论:新疆维族食管鳞状细胞癌病人Hp感染与癌细胞增殖及侵袭的恶性程度相关。
Objective：To investigate the relationship between helicobacter pylori （ Hp） infection and proliferation as well as invasion of Uygur esophagus squamous cell carcinoma.Methods： Immunohistochemistry were used to detect Hp , Ki67 and MMP2 protein in 164 cases of Xinjiang Uygur esophageal squamous cell carcinoma tissue specimens.Results： The positive rates of Hp,Ki67 and MMP2 were 81.7%（134/164）,67.1%（110/54） and 86.6%（142/164） respectively in 164 cases of esophageal squamous cell carcinoma.The expression of Ki67 in the Hp positive group of patients with esophageal squamous cell carcinoma were significantly higher than that in the Hp negative group and had positive correlation between them （rs=0.340,P〈0.01）,the expression of MMP2 in the Hp positive group were significantly higher than that in the Hp negative group and had positive correlation between them （ rs=0.739,P〈0.01）.Conclusion：The relationship between Xinjiang Uygur esophageal squamous cell carcinoma patients with Hp infection and cancer cell malignant degree of proliferation and invasion is close.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2014年第6期825-827,830,共4页
Chinese Journal of Immunology
