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miRNA对糖尿病及其心血管并发症的调控 被引量：3

Regulation of miRNA in diabetes mellitus and its cardiovascular complications
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摘要 miRNA（微小RNA,microRNA）是一类在转录后水平调控基因表达的小分子RNA.近年来多项研究表明miRNA与糖尿病及其多种并发症的发生相关.本文主要就miRNA在糖尿病及其心血管并发症中的调控作用、生物标志物的价值以及在糖尿病治疗中的应用方面作一综述,为糖尿病的诊断及治疗开拓新的思路. miRNAs （microRNAs） are small RNA which regulate gene expressions at the post-transcriptional level.Recently studies have suggested that miRNA is associated with the development of diabetes mellitus and its complications.This artcle reviews the regulation of miRNA in diabetes mellitus and its cardiovascular complications,and the biomarkers＇ value and application of miRNA in the treatment of diabetes mellitus,aiming to develop new insight for the diagnosis and treatment of diabetes mellitus.
作者 徐凤 钱玲玲 王如兴
机构地区 南京医科大学附属无锡市人民医院心内科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2014年第6期534-537,共4页 Chinese Journal of Endocrinology and Metabolism
基金 国家自然科学基金（81070157,81370303） 江苏省自然科学基金（BK2011179） 江苏省人事厅“六大人才高峰”第七批高层次项目（006） 江苏省医学重点人才资助项目（RC201134）
关键词 MIRNA 糖尿病 心血管并发症 miRNA Diabetes mellitus Cardiovascular complication
分类号 R587.1 [医药卫生—内分泌]
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  • 1American Diabetes Association. Clinical Practice Recommendations 2001. Diabetes Care 2001 24: S1-S133.
  • 2Adams KF, Schatzkin A, Harris TB, Kipnis V, Mouw T, Ballard-Barbash R and Hollenbeck A, et al. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. N Engl J Med 2006, 355: 763-778.
  • 3Akerblom H. Pathogenesis of Type 1 diabetes: environmental factors. In: Turtle J, Kaneko T and Osato S eds. Diabetes in the New Millennium. Sydney: Endocrinology and Diabetes Research Foundation, University of Sydney, 1999.
  • 4Kahn SE. Clinical review 135: the importance of β-cell failure in the development and progression of type 2 diabetes. J Clin Endocrinol Metab 2001, 86: 4047-4058.
  • 5Steppan CM, Bailey ST, Bhat S, Brown E J, Banerjee RR, Wright CM and Patel HR, et al. The hormone resistin links obesity to diabetes. Nature 2001, 409: 307-312.
  • 6Portha B. Programmed disorders of B-cell development and fimction as one cause for type 2 diabetes? The GK rat paradigm. Diabetes Metab Res Rev 2005, 21: 495-504.
  • 7Hao J, Shen W, Tian C, Liu Z, Ren J, Luo C and Long J, et al. Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rots. J Cell Mol Med 2008; doi:10.1111/ j. 1582-4934.2008.00342.x.
  • 8Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116: 281-297.
  • 9Kato M and Slack FJ. MicmRNAs: small molecules with big roles-C. elegan to human cancer. Biol Cell 2008, 100:71-81.
  • 10Scalbert E and Bril A. Implication of micmRNAs in the cardiovascular system. Curt Opin Pharmacol 2008, 8: 181-188.

共引文献29

同被引文献52

  • 1王岷,刘红雨,陈军.微小RNA研究进展[J].中国肺癌杂志,2008,11(4):582-586. 被引量：9
  • 2王先梅,严睿,杨丽霞,郭传明,齐峰,石燕昆,王燕,魏玲.心肌组织基质金属蛋白酶-1,2,9及其抑制物-1,2基因表达变化在心肌肥厚患者心肌纤维化中的意义[J].中国循环杂志,2006,21(5):382-385. 被引量：4
  • 3郑晓飞译.miRNA实验指南[M].北京.化学工业出版社,2008:1.
  • 4F, Fazi, C, Nervi, MicroRNA : basic mechanisms and transcriptional regulatory networks for cell fate determination [ J ]. Cardiovascular Research,2008,79 (4) :553-561.
  • 5J, Winter, S, Jung, S, Keller, et al. Many roads to maturity : microRNA biogenesis pathways and their regulation [ J ]. Nature Cell Biology, 2009,11 ( 3 ) : 228-234.
  • 6GiladS,Meir, EYogev Y, et al. Serum microRNAs promisingnovel biomarkers 1 [J].PLoS 0ne,2008,3 : e3148.
  • 7P. S. Mitchell, R. K. Parkin, E. M. Kroh et al. Circulating microRNAs as stable blood - based markers for cancer detection [ J]. Proceedings of the National Academy of Sciences of the United States of America, 2008,105(30) :10513-10518.
  • 8A. J. Hamilton. MicroRNA in erythrocytes[ J]. BiochemicM Society Transactions, 2010,38 ( 1 ) :229-231.
  • 9EE. Creemers, AJ. Tijsen, YM. Pinto. Circulating microRNAs : novel biomarkers and extracellular communicators in cardiovascular disease [ J ]. Circulation Research, 2012,110 ( 3 ) :483-495.
  • 10C, Li, F, Pei, X, Zhu, et al, Circulating microRNAs as novel and sensitive biomarkers of acute myocardial infarction [ J ]. Clinical Biochemistry,2012,45 ( 10 - 11 ) : 727-732.

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中华内分泌代谢杂志
2014年 第6期

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