摘要
抗N-甲基-D-天门冬氨酸受体(NMDAR)脑炎是新认识的一种严重、潜在可治的自身免疫性脑炎,可见于任何年龄,但以儿童更为常见。该病具有显著特征性,病程可分为五期,即病毒感染样症状的前驱期、精神症状期、意识障碍期、异常运动期和恢复期。该病主要治疗包括一线免疫治疗如皮质类固醇激素、静脉丙种球蛋白和血浆交换治疗;二线免疫治疗如利妥昔单抗和环磷酰胺等及肿瘤切除。该文主要介绍抗NMDAR脑炎各种治疗方法的进展、选择及治疗的局限和不足,以期对该病的临床治疗有所帮助。
Anti-N-methyl-D-aspartate receptor（anti-NMDAR） encephalitis is a new category of severe,potentially treatable autoimmune encephalitis and can appear in patients of all ages,but more frequently in children.It is a highly characteristic syndrome evolving in five stages： the prodromal phase（viral infection-like symptoms）,psychotic phase,unresponsive phase,hyperkinetic phase,and gradual recovery phase.The treatment for this disorder includes firstline immunotherapy（steroids,intravenous immunoglobulin,plasmapheresis）,second-line immunotherapy（rituximab,cyclophosphamide）,and tumor removal.Hereby the progresses,selections and shortcomings of the treatment protocols for this disease are introduced.[Chin J Contemp Pediatr,2014,16（6）： 584-588]
出处
《中国当代儿科杂志》
CAS
CSCD
北大核心
2014年第6期584-588,共5页
Chinese Journal of Contemporary Pediatrics
