摘要
抗N-甲基-D-天门冬氨酸受体(NMDAR)脑炎是近年来新认识的一种自身免疫性脑炎,儿童较多见。虽然对该病的认识不断加深,但其确切病因仍不明确。揭示抗NMDAR脑炎的病因,对于进一步阐明该病的发病机制,深入认识该病,早期诊断并尽早启动相关免疫治疗从而改善预后是十分必要的。复习国内外文献,早期认为抗NMDAR脑炎多与肿瘤尤其是畸胎瘤有关,随后的研究又发现其发病也与感染、遗传等因素等有关。该文对抗NMDAR脑炎病因的认识及演变过程进行概述。
Anti-N-methyl-D-aspartate receptor（NMDAR） encephalitis is a type of newly recognized autoimmune encephalitis which is commonly seen in children,but its precise etiology is still uncertain.To reveal the etiology of anti-NMDAR encephalitis is very necessary for understanding its pathology,and for starting immune-related therapy as early as possible to improve its prognosis.In the initial literature,tumor,especially teratoma is more related with the anti-NMDAR encephalitis.In recent research,its etiology is related to infection and heredity.This article reviews the recognition and variation of the etiology of anti-NMDAR encephalitis.[Chin J Contemp Pediatr,2014,16（6）： 567-570]
出处
《中国当代儿科杂志》
CAS
CSCD
北大核心
2014年第6期567-570,共4页
Chinese Journal of Contemporary Pediatrics
