摘要
炎症性肠病(IBD)包括克罗恩病(CD)和溃疡性结肠炎(UC),目前两者的鉴别诊断依赖临床症状、内镜检查、病理活检以及实验室和影像学检查等。近年来,IBD相关的生物标记物检测因无创、操作简单、易被患者接受而发展迅速。此外,随着全基因组关联分析(GWAS)的开展,对CD和UC相关遗传突变位点和易感基因的研究取得了较大进展,为疾病诊断提供了新方向。本文就血清分子标记物和易感基因对IBD鉴别诊断的研究进展作一综述。
Inflammatory bowel disease （IBD）includes Crohn’s disease （CD）and ulcerative colitis （UC）.The differential diagnosis between CD and UC mainly depends on clinical symptoms,endoscopy,pathological biopsy,laboratory and imaging examinations.In recent years,studies with a variety of IBD-related biomarkers develop rapidly because of its non-invasiveness,simple and easily acceptable.With the development of genome-wide association study （GWAS）,great progress has been achieved in studies of gene mutations and susceptibility genes related with CD and UC,which provides new approach for diagnosis of the disease.This article reviewed the advances in studies on serum biomarkers and susceptibility genes in differential diagnosis of IBD.
出处
《胃肠病学》
2014年第5期297-300,共4页
Chinese Journal of Gastroenterology
关键词
结肠炎
溃疡性
CROHN
病
诊断
鉴别
生物学标记
易感基因
Colitis, Ulcerative
Crohn Disease
Diagnosis, Differential
Biological Markers
Susceptibility Genes
