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巨噬细胞功能障碍与糖尿病慢性难愈创面的关系 被引量：6

Role of dysfunction of macrophage in intractable diabetic wound
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摘要 创面愈合包括凝血和炎症反应、组织形成以及组织成熟和重塑3个连续、重叠的阶段^[1]，巨噬细胞在此过程中发挥重要作用^[2]，调控表皮的KC、Fb等创面修复细胞功能的有序发挥^[3-6]。 As a result of the stimulation of proinflammatory mediators,circulating peripheral-blood mononuclear cells migrate into the wound area,and they differentiate into different phenotypes of macrophage to take different roles in healing process.Their phenotypes interchange under different microenvironments.The disturbance of cutaneous environment in diabetic patients has been shown to alter the quantity,morphology,and functions of the macrophages resulting in retardation of wound healing.Healing of intractable diabetic wound can be improved by the supplement of exogenous growth factors,which might improve healing process by regulating the phenotype of macrophage in intractable diabetic wound.This article reviews the relationship between intractable diabetic wound and macrophage to explore new methods of treating intractable diabetic wound.
作者 崔胜勇 刘琰 章雄
机构地区 上海交通大学医学院附属瑞金医院烧伤整形科
出处 《中华烧伤杂志》 CAS CSCD 北大核心 2014年第3期264-269,共6页 Chinese Journal of Burns
基金 国家自然科学基金（81170761、81270909）
关键词 糖尿病 巨噬细胞 伤口愈合 异质性 Diabetes mellitus Macrophages Wound healing Heterogeneity
分类号 R587.1 [医药卫生—内分泌]
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参考文献53

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二级参考文献22

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共引文献6

同被引文献83

  • 1付小兵.进一步重视体表慢性难愈合创面发生机制与防治研究[J].中华创伤杂志,2004,20(8):449-451. 被引量：121
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引证文献6

二级引证文献39

中华烧伤杂志
2014年 第3期

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