摘要
目的研究风湿性疾病中尿路感染大肠埃希菌对左氧氟沙星耐药性及相关危险因素。方法中国医科大学附属第一医院风湿免疫科2009年1月至2013年12月125株住院患者清洁中段尿培养所分离出大肠埃希菌,依据是否耐药分为两组。分析耐药组相关危险因素。结果 5年来大肠埃希菌对左氧氟沙星耐药率呈逐渐上升趋势。耐药组对氨苄西林、环丙沙星、头孢曲松、哌拉西林、复方新诺明的耐药率高于非耐药组,两组间差异有统计学意义(P<0.05)。慢性病程、既往喹诺酮类药物应用史、既往尿路感染、菌株产ESBLs为耐药危险因素。各风湿性疾病间耐药率比较差异未见统计学意义。结论风湿性疾病尿路感染危险因素与其他疾病尿路感染危险因素类似。临床工作中应加强对危险因素监视和控制。
Objective To investigate drug resistance to levofloxacin of Escherichia coli isolated from rheumatic disease patients complicated by urinary infection and its related risk factors. Methods 125 strains of Escherichia coli isolated from rheumatic disease inpatients with urinary infection from 2009 to 2013 were divided into two groups according to whether they are resistant to levofloxaxin, then the possible risk factors for the resistance were analyzed. Results A rising trend of the levofloxaxin resistance rate was seen in the 5-year period. The resistance rates in the levofloxaxin-resistant group to ampicillin, ciprofloxacin, ceftriaxone, piperacillin and cotrimoxazole were higher, and the differences between two groups are statistically significant （ P 〈 0.05 ）. Previously use of quinolones, urinary infections, and bacterium producing extended spectrum B lactamas appeared to be the independent risk factors of levofloxaxin resistance. Conclusion There are similar risk factors for levofloxaxin resistance in rheumatic disease patients to those in other diseases as previously reported. It is important to monitor risk factors in clinical practice.
出处
《中国微生态学杂志》
CAS
CSCD
2014年第6期683-686,共4页
Chinese Journal of Microecology
关键词
风湿性疾病
大肠埃希菌
尿路感染
左氧氟沙星
耐药
Rheumatic diseases
Escherichia coli
Urinary tract infections
Levofloxacin
Drug resistance
