摘要
目的:评价国产Amplatzer蘑菇伞介入治疗中老年动脉导管未闭(patent ductus arteriosus,PDA)的近中期临床疗效及安全性。方法:选择2007年1月至2011年12月我院收治的32例中老年PDA患者,经临床、心电图、X线及经胸超声心动图(TTE)检查确诊,均成功行介入治疗。术后行心电图、X线胸片、TTE随访。结果:32例均1次封堵成功,成功率100%。无重要并发症发生。随访X线胸片显示肺血较术前减少,心胸比率不同程度缩小。术后48小时(32例)超声心动图显示左房内径(LAD)、左室舒张末内径(LVDd)及肺动脉收缩压(PASP)较封堵前明显缩小(P<0.01);术后1、3、6月(32例)超声心动图随访显示LAD及LVDd、PASP进一步缩小;术后1年(30例)、术后2年(20例)、术后3年(12例)、术后4年(5例)超声心动图随访显示心脏大小及肺动脉收缩压恢复正常。结论:国产Amplatzer蘑菇伞介入治疗中老年PDA具有操作简单、创伤小、安全且技术成功率高、住院时间短等优点,近中期疗效明确,并发症少。
Objective： To evaluate the short and intermediate term efficacy as well as safety of transcatheter closure by homemade Amplatzer mushroom occluder of patent ductus arteriosus in the treatment of middle-aged or geratic patients. Methods： 32 cases with PDA who were confirmed by clinical manifestation, electrocardiogram （ECG）, X-ray fluoroscopy, transthoracic color Doppler echocardiography （TTE） from January 2007 to December 2011 were selected and received the transcatheter occlusion. Then the follow-ups were conducted. Results： 32 cases were all successfully occluded with the rate of 100%. In follow-ups, X-ray fluoroscopy showed pulmonary venous pleonaemia reduced and cardio-thoracic ration decreased. After 48 hours, the LAD, LVDd and PASP reduced obviously （P〈0.01）; after 1 year （30 cases）, 2 years （20 cases）, 3 years （12 cases） and 4 years （5 cases）. There was no death, complication or therapy. Conclusion： Transcatheter closure of PDA in middle-aged or geratic patients using the homemade Amplatzer mushroom occluder was safety and efficacy with easy procedure, less complication, high successful rate and shorter hospitalization.
出处
《现代生物医学进展》
CAS
2014年第19期3703-3705,3778,共4页
Progress in Modern Biomedicine
关键词
动脉导管未闭
介入治疗
中老年
近中期疗效
国产封堵器
Patent ductus arteriosus
Interventional therapy
Middle-aged patients
Short and intermediate term efficacy
Homemade occluder
