摘要
目的:研究白藜芦醇对异丙肾上腺素所致大鼠心肌肥厚的保护作用。方法:以异丙肾上腺素诱导制备大鼠心肌肥厚模型,40 mg/kg和80 mg/kg的白藜芦醇灌胃给药5、15周后,观察大鼠血流动力学指标、心输出量(CO/BW)、心脏指数(HMI)、左心室指数(LVMI)以及血清心房利钠肽(ANP)、脑钠肽(BNP)含量的变化。结果:与模型组比较,白藜芦醇在5、15周两个时间点均能显著增加心输出量,提高心肌收缩功能,改善心肌舒张功能,并能有效降低ANP、BNP含量,降低HMI、LVMI。结论:白藜芦醇对异丙肾上腺素所致心肌肥厚具有抑制作用。
Objective： To explore protective effects of resveratrol on isoproterenol induced cardiac hypertrophy in rats. Methods： Myocardial injury in rats was induced by subcutaneous injection of isoproterenol. After we infused 40, 80 mg/kg dosages of resveratrol into rats stomach for 5, 15 weeks, It were determined and analysed that hemedynamic parameters, CO/BW, LVMI, HMI, ANP and BNP. Results： Compared with model group. In the two time points of 5 and 15 weeks, resveratrol could significantly increase cardiac output, improve myocardial systolic and diastolic, decrease the contents and levels of ANP, BNP, HWI and LVMI （ P 〈 0.05 ）. Conclusion： Resveratrol have inhibitory effect on isoprotcrenol induced cardiac hypertrophy in rats.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2014年第1期34-36,共3页
Pharmacology and Clinics of Chinese Materia Medica
关键词
白藜芦醇
心肌肥厚
异丙肾上腺素
resveratrol （ 白藜芦醇）
cardiac hypertrophy
isoproterenol
