摘要
目的 探讨急性坏死性胰腺炎 (ANP)胰腺微循环血供障碍的原因 ,进一步阐明奥曲肽治疗ANP的可能机制。方法 实验研究分A、B、C 3组 ,每组 8只大鼠 ,共 2 4只 ,随机分组。A组 :空白对照组 ;B组 :ANP模型组 ;C组 :奥曲肽治疗组。分别测定每组血液中TXB2 、PGI2 及PGE2 含量。结果 实验性急性坏死性胰腺炎早期 ( 2h) ,血液中TXB2 含量显著升高 ,PGI2 则显著降低 ,PGE2 无显著变化。使用奥曲肽治疗ANP后 ,其血液中TXB2 显著降低 ,PGI2 显著升高 ,PGE2 无显著变化。结论 奥曲肽可能通过改变ANP血液中TXB2 、PGI2 水平 ,升高PGI2 及TXB2 比值 ,从而改善全身各脏器 ,特别是胰腺组织微循环血供 ,改善病变脏器的预后。
Objective To explore causes for microcirculatory disorder after acute necrotizing pancreatitis (ANP) and further clarify mechanism of treatment of ANP by Octreotide. Methods Twenty-four rats were equally randomized into the control group, ANP group and Octreotide-treated group. The blood levels of TXB 2, PGI 2 and PGE 2 were measured in all the 3 groups. Results The blood level of TXB 2 significantly increased, that of PGI 2 remarkably decreased and that of PGE 2 remained unchanged in ANP group as compared with the control. In the Octreotide-treated group, the blood level of TXB 2 significantly decreased, that of PGI 2 markedly increased and that of PGE 2 remained unchanged. Results Octreotide can improve the prognosis of ANP by regulating blood levels of TXB 2 and PGI 2 and increasing the ratio of PGI 2/TXB 2 to ameliorate microcirculation of organs, especially the pancreas.
出处
《中华肝胆外科杂志》
CAS
CSCD
2001年第3期165-167,共3页
Chinese Journal of Hepatobiliary Surgery
