摘要
目的:观察五味子颗粒辅助联合环磷酰胺+阿霉素+5-氟尿嘧啶(CAF)化疗方案对乳腺癌多药耐药的逆转作用及对多药耐药相关蛋白(MRP)的影响。方法:72例MRP阳性表达乳腺癌患者按住院前后顺序分为实验组和对照组各36例。对照组采用CAF化疗方案进行治疗,实验组在对照组治疗的基础上给予五味子颗粒辅助治疗。两组疗程均为8周。观察两组的临床疗效、生存时间、中位缓解期、治疗后副作用及逆转多药耐药相关蛋白(MRP)的有效率。结果:实验组总有效率为58.33%,明显优于对照组的30.56%(P<0.05);实验组中位缓解期为12.5个月,明显好于对照组的7.5个月(P<0.05);治疗后实验组逆转MRP有效率为33.3%,明显高于对照组的2.78%(P<0.05)。结论:五味子颗粒联合CAF化疗方案可以有效缓解乳腺癌患者的临床症状,可有效逆转MRP介导的肿瘤多耐药性,在肿瘤治疗中发挥一定作用。
Objective： To observe multidrug resistance reversal and the influence on MRP of breast cancer by Wuweizi granule combined with Cyclophosphamide ＋ Doxorubicin ＋ 5-Fluorouracil（CAF） chemotherapy. Method： Seventy-two cases of breast cancer patients of MRP expression were randomly divided into experimental group （36 cases） and control group （36 cases） by hospitalized order. The control group received CAF chemotherapy treatment based on the control group treatment, the experimental group added Wuweizi granule. The two groups were treated for 8 weeks. Observation two groups of the clinical efficacy, survival time, median remission, side effects and reversal effective rate of MRP in the two groups were observed after the treatment. Result： The total efficiency of the experimental group 58.33% , was higher than the control group 30.56% （P 〈 O. 05 ）. The median remission of the experimental group 12.5 months was better than the control group 7.5 months （P 〈0. 05）. The reversal effective rate of MRP in the experimental group 33.3% , was significantly higher than the control group 2.78% （P 〈 0.05）. Conclusion： Wuweizi granule combined with CAF chemotherapy can effectively alleviate the clinical effects of breast cancer patients, which can effectively reverse multidrug resistance by MRP, plays a certain role.
出处
《中国实验方剂学杂志》
CAS
北大核心
2014年第12期241-243,共3页
Chinese Journal of Experimental Traditional Medical Formulae
