摘要
鬼臼脂素类衍生物体内作用模式之一是经氧化生成醌式中间体而进一步发挥作用 .本文作者设计合成了 4 去氧 4β 酰胺基 3′ ,4′ 邻醌式鬼臼脂素 ,测试了其体外抑制KB细胞和L12 10白血病细胞活性 ,并对结果进行了探讨 .
Considering that one of the mechanisms acting upon tumour cells of podophyllotoxin derivatives in vivo was to form semiquinone on ring C,4 Deoxy 4β amido 3′,4′ semiquinonepodophyllotoxin was synthesized and their activities against KB cells and L1210 leukemia cells were tested.
出处
《中国药物化学杂志》
CAS
CSCD
2000年第4期239-241,共3页
Chinese Journal of Medicinal Chemistry
关键词
鬼臼脂素衍生物
抗肿瘤
合成
药理
podophyllotoxin
podophyllotoxin derivatives
antitumor
synthesis
