摘要
在无溶剂超声条件下,氨基磺酸可以高效地催化环己酮,芳香醛与芳香胺一锅反应的Mannich反应。该方法具有反应时间短,收率较高,条件温和,易于操作,后处理方便以及绿色环保等优点。
One-pot Mannich reaction of cyclohexanone, aromatic aldehydes and aromatic amines could be efficiently catalyzed by sulfamic acid under solvent-free conditions and ultrasound irradiation. Compared with traditional method, this ultrasound protocol had advantages of short reaction time,high yield,mild condition,simple work-up procedure and environmental friendly.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2014年第3期330-335,共6页
Chemical Research and Application
基金
乐山师范学院2011校级科研启动项目(Z1154)资助
关键词
MANNICH反应
超声
β-胺基酮
一锅法
氨基磺酸
无溶剂
Mannich reaction
ultrasound
β-aminocarbonyl compound
one-pot reaction
sulfamic acid
solvent-free
