摘要
间硝基苯甲醛或间氯苯甲醛与芳香胺和芳香酮在20～25℃和催化量的浓盐酸催化下能直接进行Mannich反应,用一步合成法合成15个1-芳基-3-芳胺基(3-硝基苯基)丙酮。产率为68～87％。产物结构经元素分析,IR,~1H NMR,MS鉴定。本文还讨论了反应的适宜条件。
In the presence of catalytic amount of hydrochloric acid, the Mannich reaction of 3-nitrobenzaldehyde (3-Chlorobenzaldehyde), aromatic amines and aromatic ketones can take place directly at 20 - 25℃. Fifteen corresponding Mannich bases ( 1a - 1o), 1-aryl-3-arylamino [ 3-nitro (chloro) phenyl ] acetone, were prepared with 68 - 87% yield. Some compounds were verified by elemental analyses, IR, 1H NMR, MS. The reaction conditions were also discused in this paper.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
1996年第3期218-222,共5页
Chinese Journal of Organic Chemistry
关键词
MANNICH反应
MANNICH碱
芳香胺
芳香酮
芳醛
Mannich reaction, Mannich bases, 3-nitrobenzaldehyde, 3-chlorobenzaldehyde, aromatic amines, aromatic ketones
