摘要
目前针对晚期胃癌的化疗方案不断涌现,但晚期胃癌患者预后仍然较差,分子靶向治疗是除化疗之外治疗晚期胃癌的又一重要方向。针对诸多影响胃癌发生发展的靶点如表皮生长因子受体、人类表皮生长因子受体2、血管内皮生长因子、血管内皮生长因子受体、环氧合酶2等,出现了各种靶向治疗药物,多项Ⅱ/Ⅲ期临床研究正在进行或已经完成。本文结合最新研究报道,对胃癌分子靶向治疗的最新进展作一综述。
Despite chemotherapy regimens for advanced gastric cancer keep emerging,the patients still have poor prognosis.Molecular targeted therapy is another important direction for the treatment of advanced gastric cancer.Various drugs for molecular targeted therapy have been developed targeting epidermal growth factor receptor(EGFR),human epidermal growth factor receptor-2(HER-2),vascular endothelial growth factor(VEGF)and its receptor(VEGFR),and cyclooxygenase-2(COX-2);a number ofⅡ/Ⅲclinical trial have been completed or being conducted.The aim of this review is to summarize the recent progress on molecular targeted therapy for gastric cancer.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2014年第3期305-311,共7页
Academic Journal of Second Military Medical University
关键词
胃肿瘤
分子靶向治疗
表皮生长因子受体
血管内皮生长因子类
血管内皮生长因子受体
环氧合酶2
stomach neoplasms
molecular targeted therapy
epidermal growth factor receptor
vascular endothelial growth factors
vascular endothelial growth factor receptor
cyclooxygenase-2
