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曲妥珠单抗治疗人表皮生长因子受体2阳性胃癌研究进展 被引量：2

Advance of trastuzumab in treatment of human epidermal growth factor receptor-2-positive gastric cancer
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摘要 曲妥珠单抗是靶向人表皮生长因子2(HER-2/neu,HER2)的单克隆抗体。胃癌中HER2的阳性率为22.1%,曲妥珠单抗联合化疗可明显改善HER2阳性进展期胃癌患者的生存。曲妥珠单抗将成为胃癌治疗的重要药物。本文对曲妥珠单抗治疗胃癌的基础和临床研究结果进行综述。 Trastuzumab is a monoclonal antibody directed against the human epidermal growth factor receptor 2 （HER-2/neu, HER2）. The HER2 positive rate is 22.1% in patients with gastric cancer. Trastuzumab in combination with chemotherapy could improve the survival of patients with HER2-positive advanced gastric cancer. Trastuzumab will become an important drug in gastric cancer. This paper reviews the basic and clinical studies of trastuzumab in the treatment of gastric cancer
作者 李晓玲 徐建明
机构地区 首都医科大学宣武医院药剂科 中国人民解放军
出处 《中国新药与临床杂志》 CAS CSCD 北大核心 2010年第4期260-263,共4页 Chinese Journal of New Drugs and Clinical Remedies
关键词 胃肿瘤 曲妥珠单抗 HER-2/NEU stomach neoplasms trastuzumab HER-2/neu
分类号 R735.2 [医药卫生—肿瘤]
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参考文献11

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二级参考文献37

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中国新药与临床杂志
2010年 第4期

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