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对氧磷酶(Paraoxonase)的测定方法与临床意义 被引量：4

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摘要 对氧磷酶 (Paraoxonase)是结合在高密度脂蛋白 (HDL)上的一种有机磷三酯化合物水解酶。最近研究表明 ,对氧磷酶可以保护低密度脂蛋白 (LDL)的氧化 ,其活性与基因多态性被认为是动脉粥样硬化、冠心病的独立危险因素。本文综述Paraoxonase的生化特征、基因的多态性。
作者 胡红焱 邹德勇 崔云龙
机构地区 武警总医院检验科
出处 《国外医学（临床生物化学与检验学分册）》 2001年第2期73-73,76,共2页 Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine
关键词 PARAOXONASE 动脉粥样硬化 脂蛋白 对氧磷酶 生物化学
分类号 R341 [医药卫生—基础医学]
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参考文献10

  • 1Dharambir K,Saha N,Kamboh I.The codon 55 polymorphism in the paraoxonase 1 gene is not associated with the risk of coronary heart disease in Asian Indians and Chinese[].Atherosclerosis.1998
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  • 4LaDu,Mach K.Studies on human serum paraoxonase/arylerase[].Chemico Biological Interactions.1993
  • 5Mickenss B,Mackness M,Arrol S.Serum paraoxonase 55 and 192 polymorphism and paraoxonase activity and concentration in non-insulin dependent diabetets mellitus[].Chemico Biological Interactions.1993
  • 6Justin W.The Oxidation hypothesis of atherosclerosis: An update[].Annals of Clinical and laboratory Science.1997
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  • 8Mackness M,Arrol S,Mackness B.Alloenzymes of paraoxonase and effectiveness of high-density lipoproteins in protecting low-density lipoprotein against lipid peroxidation[].The Lancet.1997
  • 9Hernandz A,Gonzalvo M,Gil F.Distribution profiles of paraoxonase and choliesterase phenotypes in a Spanish population[].Chemico Biological Interactions.1999
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同被引文献36

  • 1赵赞梅,王汉斌.对氧磷酶的某些研究进展[J].毒理学杂志,2005,19(1):64-66. 被引量：10
  • 2杨玉恒,马桂芬,薛永蕙.对氧磷酶-1与有机磷农药中毒的关系[J].河北医药,2005,27(11):856-857. 被引量：4
  • 3王青定,孙曼霁.人血清中的对氧磷酶[J].生物化学与生物物理进展,1996,23(3):217-221. 被引量：2
  • 4Miguel A. Sogorb , EugenioVilanova, Victoria Carrera. Future applications of phosphotriesterases in the prophylaxis and treatment of organophospoms insecticide and nerve agent poisonings [ J ]. Toxicology Letters, 2004, 151 (1): 219-233.
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  • 6Daniel R, Eric C, Patrick M. Human paranxonase: A promising approach for pre-trealment and therapy of organophoaphorus poisoning [J] . Toxicology, 2007, 233 (1-3): 47-59.
  • 7Kuo CL, La Du BN. Comparison of Purified Human and Rabbit Serum Paraoxonases [ J ]. Drug Metab Dispos, 1995, 23 ( 9 ) : 935-944.
  • 8Petrikovics I, Papahadjopoulos D, Hong K, et al. Comparing therapeutic and prophylactic protection against the lethal effect of paraoxon [J]. Toxicology Science, 2004 , 77 (2): 258-262.
  • 9Catherine MH, Ashok M, Wilfred C. Altering the substrate specificity of organophosphorus hydrolase for enhanced hydrolysis of chlorpyrifos [ J ]. Applied and Environmental Microbiology, 2004, 70 ( 8 ) : 4681-4685.
  • 10La Du BN, Adkins S, Kuo CL, et al. Studies on human serum paraoxonase/arylesterase [ J ]. Chem Biol Interact, 1993, 87 ( 1/ 3): 25-34.

引证文献4

二级引证文献10

国外医学（临床生物化学与检验学分册）
2001年 第2期

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