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人血清中的对氧磷酶 被引量:2

Paraoxonase in Human Serum
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摘要 对氧磷酶能够水解强毒性农药对氧磷而受到许多学者的重视,但国内尚未见报道文章综述了人血清中对氧磷酶的分布、特异性、分离纯化、多态性、遗传学特性、与疾病的关系以及对有机磷化合物毒性的防护作用.这有利于进一步研究对氧磷酶的生物学性质、生理功能及其应用. Paraoxonase can hydrolyzes paraoxon, the most highly toxic pesticide,and was paid good attention in recent decades, but there was no published rePOrt in our country. Its existence, substrate specificity, isolation, purification, polymorphism, genetic properties, relations with some diseases, and its protectionagainst organophosphorus compounds are introduced. It is beneficial for further studies of itsbiological properties, physiological function andapplication.
出处 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 1996年第3期217-221,共5页 Progress In Biochemistry and Biophysics
关键词 对氧磷酶 血清 分离 paraoxonase isolation Purification substrate specificity polymorphism
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  • 1Chemnitius JM, Losch H, Iosch K, et al. Organophosphate detoxicating hydrolases in different rertebrate. Comp Biochem Physiol C, 1983,76: 85-93.
  • 2Saha N, Roy AC,Teo SH, et al. Influence of serum paraoxonase polymorphism on serum lipids and apolipoproteins. Clin Genet, 1991,40:277-282.
  • 3Kelso GJ, Stuart WD, Richter RJ, et al. Apolipoprotein J is associated with paraoxonase in human plasma. Biochemistry, 1994,33:832-839.
  • 4Sorenson R C, Parmo SR, Liang CK, et al. Reconsideration of the catalytic center and mechanism of memorialion paraoxonase/arylesterase. Proc Natl Acad Sci USA, 1995,92:7187-7191.
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  • 6Adkins S, Gan KN, Mody M, et al. Molecular basis for the polymorphic forms of human serum paraoxonase/arglesterase: Glutamine or Arginine at position191,for the respective A or B allozymes. Am J Hum Genet, 1993,52:598-608.
  • 7Hassett C, Richter R J, Humbert R, et al. Characterization of eDNA clones encoding rabbit and human serum paraoxonase: the mature protein retains its signal sequence. Biochemistry, 1991,30:141-149.
  • 8Zama T, Murata M, Matsubara Y, et al. A192 Arg variant of the hmnan paraoxonsse (HUMPONA) gene polymorphism is associated with an increased risk for coronary artery disease in the Japanese. Arterioscler Thromb Vasc Biol,1997,17: 3565-3569.
  • 9Cerry N,Mackness M,Durrington P,et al. Paraoxonase (PON-1) polymorphisms in farmers attributing ill health to sheep dip. Lancet,2002,359:763-764.
  • 10Reiner E. Recommendations of the IUBUM Nomenclature Committee:Comments Concerning Classification and Nomenclature of Esterases Hydrolysing Organophosphorus Compounds. Chem - biol. Interactions 1993; 87:15-16

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