摘要
目的 探讨内皮素在慢性阻塞性肺部疾病发病过程中的变化及其意义。方法 采用放免法测定 80例肺原性心脏病患者和 76例慢性支气管炎患者的血浆内皮素含量 ,同时进行动脉血气监测 ,并与健康人作对照。结果 ①肺原性心脏病组血浆内皮素明显增高 ,其平均值为 (8 76± 0 71)pg·ml- 1,与慢性支气管炎组及对照组比较有明显差异 (4 90± 0 76pg·ml- 1,P <0 0 5;2 87± 0 95pg·ml- 1,P <0 0 0 1)。②血浆内皮素含量与PaO2 呈线性关系 ,而与PaCO2 无关。结论 内皮素增高可促进肺动脉高压形成 ,在肺原性心脏病的发生及发展中起重要作用 ,缺氧可能是致内皮素增高的重要原因。
Objective To investigate the cl inical significance of changes in plasma endothelin levels in the course of deve lopment of chronic obstructive pulmonary disease(COPD).Methods Radioimmunoassay was used to determin e plasma endothelin levels in 80 patients with cor pulmonale and 76 patients with chronic bronchitis.At the same time,artery blood gas analysis were also done in all patients. Results ①Average plasma level of endothelin wa s significantly higher in cor pulmonale group than that in chronic bronchitis and in control group(8 76±0 71 pg·ml -1 versus 4 90±0 76 pg·ml -1 and 2 87±0 95 pg·ml -1 , P <0 05, P <0 001 respectively) ②Linear correlation was observed in plasma level of endothelin with PaO 2,but no correlation with PaCO 2.Couclusion The in crease of endothelin which may promote the formation of high pulmonary pressur e,may play an important role in occuring and progressing of cor pulmonale.Hypoxa emia may be the important cause involved in increase of endothelin.
出处
《兰州医学院学报》
2001年第1期17-18,共2页
Journal of Lanzhou Medical College
