摘要
目的探讨维持血液透析患者红细胞谷胱甘肽S转移酶(GST)水平及其与透析充分性及炎症因子的相关性。方法根据单位室模型尿素指数值(spKt/V)将84例长期维持血液透析的终末期患者分为血液透析充分组(spKt/V≥1.3)33例以及血液透析不充分组(spKt/V<1.3)51例,另选取50例健康体检者为对照组,对比分析三组患者相关临床及生化指标的差异。结果血液透析组GST、肌酐、超敏C反应蛋白(hs-CRP)、转铁蛋白饱和度(TSAT)、甲状旁腺素(PTH)、白细胞介素-2、6、8(IL-2、6、8)及肿瘤坏死因子-a(TNF-a)水平显著高于对照组(P<0.05),且血液透析不充分组GST、IL-2、6、8、TNF-a水平显著高于血液透析充分组(P<0.05)。经Pearson’s相关分析可知,GST与spKt/V、IL-2、IL-6、IL-8、TNF-a呈正相关(均P<0.05),而与肌酐、hs-CRP、TSAT、PTH无相关性(P>0.05)。对51例血液透析不充分患者调整透析方案后有23例患者spKt/V≥1.3,经调整后患者GST水平显著低于调整前,但仍高于充分透析组。结论维持血液透析患者GST水平与spKt/V及相关炎症因子具有一定的相关性,通过测定GST可有效反映血液透析充分性,对临床调整血液透析方案具有指导意义。
Objective To investigate the levels of glutathione S-transferase （GST）and adequacy and relevance of in-flammatory cytokines with hemodialysis patients erythrocyte.Methods 84 cases of long-term hemodialysis patients were deviced into hemodialysis group （spKt/V≥1.3）33 cases and inadequate hemodialysis group （spKt/V〈1.3）51 cases.50 healthy volunteers were selected as the control group.The clinical and biochemical of three groups were com-paratived.Results The levels of C-reactive protein （hs-CRP）,transferrin saturation （TSAT）,parathyroid hormone （PTH）,interleukin-2,6,8 （IL-2,6,8 ）and tumor necrosis factor-α （TNF-α）of hemodialysis were significantly higher than control group（P 〈0.05）,and the levels of GST,IL-2,6,8,TNF-α of inadequate hemodialysis group were higher than hemodialysis adequacy group （P 〈0.05）.The Person＆#39;s single-factor analysis shows,GST and spKt/V,IL-2,6,8, TNF-α was positively correlated （all P 〈0.05）,and creatinine,hs-CRP,TSAT,PTH was not correlated （P〉0.05）.51 cases of inadequate hemodialysis patients after adjustment program has 23 dialysis patients spKt/V≥1.3,after adjust-ment GST patients was significantly lower than before the adjustment,but still higher than adequate dialysis.Conclusion hemodialysis patients GST levels spKt/V and related inflammatory factors has some relevance,by measuring the GST can effectively reflect hemodialysis adequacy,adjusting for clinical hemodialysis program has guiding significance.
出处
《中国实验诊断学》
2014年第5期749-752,共4页
Chinese Journal of Laboratory Diagnosis
关键词
红细胞谷胱甘肽转移酶
血液透析
炎症因子
erythrocyte glutathione S-transferase
hemodialysis
inflammatory cytokines
