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烟草烟雾染毒小鼠精子形态和睾丸某些生化指标的变化 被引量:2

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摘要 目的观察烟草烟雾染毒对小鼠精子畸形率及睾丸组织匀浆中超氧化物歧化酶(SOD)、丙二醛(MDA)、酸性磷酸酶(ACP)、乳酸脱氢酶(LDH)和一氧化氮合成酶(NOS)活性的影响。方法每只雄鼠计数500条完整的精子,计算出精子畸形率;用分光光度法检测小鼠睾丸组织中SOD、MDA、ACP、LDH和NOS的活性。结果小鼠精子畸形率随着染毒时间的延长而增加,烟草烟雾染毒可引起小鼠睾丸组织匀浆中SOD、MDA和NOS活性显著升高,ACP和LDH活性显著下降。结论烟草烟雾染毒可致小鼠精子形态和睾丸某些生化指标发生变化。
出处 《毒理学杂志》 CAS CSCD 北大核心 2014年第2期117-120,共4页 Journal of Toxicology
基金 国家自然科学基金(81260433) 新疆医科大学2013年度科研创新基金项目(XJC2013224)
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