摘要
目的研究钆塞酸二钠（Gd—EOB-DTPA）增强MRI在肝脏功能定量评估中的临床价值。方法前瞻性纳入2012年6月至2013年6月收治的8例肝硬化和6例原发性肝癌患者。所有患者均于术前和术后进行Child-Pugh分级。术前测定吲哚菁绿15min储留率（ICGR15）；并行肝脏Gd—EOB-DTPA增强MRI扫描，获得感兴趣区（ROI）和主动脉区的时间一强度曲线，再利用反卷积方法计算肝脏摄取分数（HEF）。分析HEF与ICGR15的相关性以及术前、术后Child—Pugh分级变化与HEF的关系。结果单纯肝硬化患者平均HEF[（80．51±7．77）％]与ICGR15[（13．99±7．65）％]高度相关（r=-0．971，P〈0．05）。原发性肝癌组平均HEF[（87．01±8．10）％]与平均ICGR15[（9．67±4．60）％]也呈高度相关（r=-0．855，P〈0．05）。术前HEF值越低，术后发生肝脏功能衰竭的可能性越大。肝癌肿瘤区HEF14．89％-35．90％，平均为21，80％。结论钆塞酸二钠增强MRI能准确定量评估肝脏储备功能，可应用于原发性肝癌患者术前检查。
Objective To explore the value of Gd-EOB-DTPA enhanced magnetic resonance imaging （MRI） in the quantitative evaluation of liver function. Methods Between June 2012 and June 2013, we prospectively included 8 patients with cirrhosis and 6 patients with primary hepatic carcinoma （PHC）. The Child-Pugh classification, indocyanine green retention rate at 15 minutes （ICGRI5） , and Primovist enhanced MR imaging were performed in all the patients. Using the deconvolution method to calculate hepatic extraction fraction （HEF） , the correlations between HEF and Child-Pugh and ICGR15 were analyzed. Resuits For cirrhosis, there was a signifieant correlation between the HEF and the ICGR15 by the Pearson correlation coefficient （r = -0. 971, P 〈 0.05 ）. For hepatocarcinoma, there was also a significant correlation （r= -0.855, P〈0.05）. The average HEF of PHC was 21.80% （14.89%-35.90%）. Conclusions The Gd-EOB-DTPA enhanced MRI accurately evaluated liver function quantitatively. It may be used for patients with PHC for preoperative examination.
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2014年第5期324-327,共4页
Chinese Journal of Hepatobiliary Surgery
关键词
肝脏功能
磁共振成像
造影剂
钆塞酸二钠
Liver function
Magnetic resonance imaging
Contrast Media
Gadoxate disodium
