摘要
目的比较D5和D6的冻融囊胚移植后的种植率、临床妊娠率、活产率和流产率，为囊胚复苏日的胚胎选择提供指导。方法回顾性分析2012年3月～12月在北京协和医院辅助生殖中心进行复苏囊胚移植的178个周期的患者资料，按照冷冻前形成囊胚的时间（D5或D6）进行分组，比较两组的种植率、临床妊娠率、活产率和流产率。结果共复苏178个周期，复苏囊胚303个，复苏后所有囊胚腔均扩张，复苏成活率100％。平均移植囊胚数（1．70±0．46）个。178个周期均进行了胚胎移植，囊胚种植率为59．4％（180／303），临床妊娠率70．8％（126／178），失访5例，活产率55．6％（99／178），流产率17．5％（22／126）。D5冻融囊胚的临床妊娠率（78．0％），显著高于D6冻融囊胚的临床妊娠率（64．6％）（P〈0．05）。D5冻融囊胚的种植率（64．3％）、活产率（63．4％）高于D6冻融囊胚的种植率（51．0％）和活产率（49．0％），但差异无统计学意义（P值分别为0．089和0．053）。D5的流产率（14．3％）要低于D6（20．6％），但差异无统计学意义（P=0．324）。结论D5和D6的囊胚冷冻复苏后均有较好的种植率、临床妊娠率和活产率，但是D5的囊胚临床结局要优于D6的囊胚。囊胚复苏移植时可以优先考虑选择D5的胚胎。
Objective. To compare the implantation rate, pregnancy rate, live birth rate and miscarriage rate following transfer of frozen-thawed embryos on day 5 and on day 6. ：Methods： This retrospective study included 178 frozen-thawed blastocysts transfer cycles in our productive center from March 2012 to December 2012. The patients were grouped by the day of blastocyst formed（day 5 or day 6）. And the implantation irates,pregnancy rates,live birth rates and miscarriage rate f were compared between the two groups. Results： A total of 303 blastocysts were warmed with 100% survival rate in 178 frozen-thawed blastocyst transfer cycles. The implantation rate,pregnancy rate,live birth rate and miscarriage rate were 59.4% ,70.8% ,55.6% and 17.5% respectively. The pregnancy rate was significantly higher in blastocysts cryopreserved on day 5 group than that on day 6 group （P = 0. 049）. There were no differences in implantation rate,live birth rate and miscarriage rate between the two groups（P〉0. 05）. Conclusions. The clinical outcome of blastocyst on day 5 is better than that of embryos on day 6. The blastocysts on day 5 have higher inherent viability than blastocysts on day 6.
出处
《生殖医学杂志》
CAS
2014年第5期356-360,共5页
Journal of Reproductive Medicine
关键词
冷冻复苏胚胎移植
囊胚
Frozen-thawed embryo transfer
Blastocyst
