摘要
目的：观察代谢异常人群血清总胆碱酯酶（ CHE）的变化，探讨其在糖尿病、脂肪肝、超重发病发展中的作用和意义。方法收集来本院体检的人群，分为糖尿病、脂肪肝、超重组、糖尿病合并脂肪肝组和正常对照组，测定各组血清总胆碱酯酶水平。结果糖尿病、脂肪肝、超重组和糖尿病合并脂肪肝组的血清CHE水平均高于正常组[（依次为（8943±1896） U/L，（9716±1673）U/L，（8798±1710）U/L，（9385±1687）U/L vs （8028±1621）U/L]，脂肪肝组升高最显著。而糖尿病合并脂肪肝组的血清CHE水平与单纯糖尿病组或脂肪肝组差异均无统计学意义（ P ＞0.05）。有代谢综合征成分组的CHE均高于无代谢综合征成分组的患者[（8786±1514）U/L，（9141±1771）U/L，（9705±1628）U/L，（9138±1768）U/L，（9530±1607） U/L vs （7821±1324U/L]，但CHE并不是随着代谢综合征成分增多呈递增改变。血清CHE的水平与年龄呈负相关（ P ＝0.00），而与甘油三酯、总胆固醇、体质量指数呈正相关（ P ＝0.00）。结论血清胆碱酯酶在糖尿病、脂肪肝、超重等疾病中均升高，可能是其发病的危险因素，控制CHE水平对改善代谢疾病有一定的临床指导作用。
Objective To investigate the change of plasma cholinesterases （CHEs） in the people with diabetes or fatty liver or overweight , and explore the role of CHE in these diseases .Methods The plasma CHEs in 2834 subjects were detected , and these subjects were divided into five groups , including diabetes , fatty liver , overweight , diabetes with fatty liver , and the normal groups . Results The plasma CHE activities in diabetes group , fatty liver group , overweight group , and diabetes with fatty liver group were all higher than the normal group [（8943 ±1896）U/L, （9716 ±1673）U/L, （8798 ±1710）U/L, （9385 ±1687）U/L vs （8028 ±1621） U/L], and the CHE level in the fatty liver group was highest among five groups .However, the CHE level in diabetes group or fatty liv-er group was not significantly different from that in the diabetes with fatty liver group .The CHE level of the people with components of metabolic syndrome （MS） was significantly higher than that without MS component [（8786 ±1514）U/L, （9141 ±1771）U/L, （9705 ±1628）U/L, （9138 ±1768）U/L, （9530 ±1607）U/L vs （7821 ±1324）U/L]）,but the CHE level was not increased gradually with the increased MS component.The plasma CHE had a negative correlation with age （ P =0.00）,but it had a positive correlation with triglyceride （TG）, total cholesterol （TC）, and body mass index （BMI）（ P =0.00）.Conclusions The plasma CHE activity was el-evated in diabetes group , fatty liver group , and overweight group , which might be a risk factor in these diseases .Controlling the plas-ma CHE might help to treat the metabolism diseases .
出处
《中国医师杂志》
CAS
2014年第4期479-481,共3页
Journal of Chinese Physician
关键词
胆碱酯酶类
血液
糖脂类
代谢
糖尿病
脂肪肝
超重
Cholinesterases/blood
Glycolipids/metabolism
Diabetes mellitus
Fatty liver
Overweight
