摘要
目的：探讨新生儿苯丙酮尿症（PKU）及先天性甲状腺功能低下（CH）筛查的临床效果。方法：回顾性分析2007年1月～2012年12月在成都市妇女儿童中心医院及在成都市及服务地区各产科执业单位出生的活产新生儿的PKU和CH筛查、诊断与治疗情况。统计所有新生儿的体格及智力发育情况。结果：筛查的938 943例新生儿中有364例CH患者,26例PKU患者。364例CH患儿的体重、身高和头围均符合正常同龄儿童的标准。患儿智商〉85的占92.0%,精神发育指标评分〉85的占88.0%,5岁时儿童智商〉85的为100.0%。结论：对新生儿进行PKU及CH筛查可以有效保障儿童体格及智力的正常发育,保障儿童健康成长,值得临床继续研究并推广。
Objective： To explore the clinical effects of neonatal phenylketonuria （PKU） and congenital hypothyroidism （CH） screening. Methods： PKU and CH screening, diagnosis and treatment of live neonates born in the hospital and obstetrical hospitals in Chengdu city from January 2007 to December 2012 were analyzed retrospectively; physical development and mental development of all the neonates were analyzed statistically. Results： Among 938 943 neonates, 364 neonates were diagnosed as CH and 26 neonates were diagnosed as PKU; body weight, body height and head circumstance of 364 neonates with CH were conform to norms of children in the same age groups; intelligence quotient （IQ） of 92. 0% of the neonates was more than 85, mental development index score of 88.0% of the neonates was more than 85, IQ of all the children at five years was more than 85. Conclusion ： Neonatal PKU and CH screening can effectively ensure normal physical and mental development of children, guarantee healthy growth of children, which is worthy further clinical studies.
出处
《中国妇幼保健》
CAS
北大核心
2014年第15期2375-2377,共3页
Maternal and Child Health Care of China
基金
四川省成都市医药卫生科技计划项目〔2012ZL078〕
