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血根碱抗肿瘤作用研究进展 被引量：6

Progress on Anti-tumor Effect of Sanguinarine
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摘要 血根碱(Sanguinarine)是一种苯菲啶异喹啉类生物碱,具有抗菌、消炎镇痛、抗肿瘤及杀虫等作用,已经作为一种新型药物用于医学和农业生产。论文主要介绍了血根碱抗肿瘤作用的研究概况,并对其作用机理进行了探讨,以期为该药在临床中的合理应用提供参考。 Sanguinarine is a benzene phenanthridine isoquinoline alkaloid which can anti-bacterial,anti-in-flammatory,anti-tumor,insecticidal effects and can induce apoptosis,and has been as a new type of drug in medicine and agricultural production.This review summarized research progress of sanguinarine on anti-tumor effects and its mechanism,which could provide a reference for the application of sanguinarine in clinical.
作者 林海 薛立群 杨青
机构地区 湖南农业大学动物医学院
出处 《动物医学进展》 CSCD 北大核心 2014年第5期105-107,共3页 Progress In Veterinary Medicine
基金 作物种质创新与资源利用重点实验室科学基金项目(12KFXM02) 湖南省科技计划重点项目(2012FJ2015)
关键词 血根碱 抗肿瘤 作用机理 sanguinarine antitumor effect action mechanism
分类号 S852.3 [农业科学—基础兽医学]
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参考文献20

  • 1Ahmad N, Gupta S, Husain M M, et al. Differential antiproliferative and apoptotic response of sanguinarine for cancer cells versus normal cells [J]. Clin Cancer Res, 2000, 6 (4): 1524- 1528.
  • 2Tsukamoto H, Kondo S, Mukudai Y, et al. Evaluation of anticancer activities of benzo phenanthridine alkaloid sanguinarine in oral squamous cell carcinoma cell line [J]. Anticancer Res, 2011,31(9):2841-2846.
  • 3Lee J S, Iung W K, Jeong M H, et al. Sanguinarine induces apoptosis of HT-29 human colon cancer cells via the regulation of Bax/Bcl-2 ratio and caspase-9-dependent pathway [J]. Int J Toxicol , 2012, 31(1) :70-77.
  • 4Park H, Bergeron E, Senta H, et al. Sanguinarine induces apoptosis of human osteosarcoma cells through the extrinsic and intrinsic pathways [J]. Biochem Biophys Res Commun , 2010, 399(3) : 446-451.
  • 5Aburai N, Yoshida M, Ohnishi M, et al. Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells [J]. Biosci Biotechnol Biochem , 2010, 74(3): 548-552.
  • 6Chang M C, Chan C r. Wang Y J, et al. Induction of necrosis and apoptosis to KB cancer cells by sanguinarine is associated with reactive oxygen species production and mitochondrial membrane depolarization [J]. Toxicol Appl Pharmacol, 2007, 218(2) : 143-15l.
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二级参考文献6

  • 1郁建平,赵东亮,孟祥斌,周晓秋.博落回生物碱对8种真菌的抑菌作用[J].山地农业生物学报,2006,25(1):89-91. 被引量：37
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共引文献35

同被引文献97

  • 1杜方麓,张艳,郑国栋,欧阳文.血水草地上部分亲脂性成分研究[J].中药材,2006,29(6):565-567. 被引量：9
  • 2宗永立,刘艳平.白屈菜红碱对人胃癌BGC823细胞的增殖抑制和凋亡诱导作用[J].中草药,2006,37(7):1054-1056. 被引量：23
  • 3宗永立,刘艳平.白屈菜红碱诱导细胞凋亡的机理综述[J].时珍国医国药,2006,17(10):2068-2071. 被引量：22
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引证文献6

二级引证文献13

动物医学进展
2014年 第5期

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