摘要
目的：研究急性白血病化疗后不同时期应用粒细胞集落刺激因子（G—CSF）的疗效。方法：选取2010年9月～2013年7月本院收治的80例急性白血病化疗患者为研究对象，将其根据G—CSF应用时间分为A组（化疗后48h应用组，20例）、B组EANC值（1．0～1．4）×10^9／L时应用组，20例、C组ANC值（0．5～0．9）×10^9／L时应用组，20例和D组（ANC值〈0．5×10^9／L时应用组，20例，比较4组患者ANC值达到≥1．5×10^9／L的时间、G—CSF应用时间及口腔溃疡发生率。结果：A组ANC值达到≥1．5×10^9／L时间、G—CSF应用时间均短于B组、C组及D组，B组则短于C组及D组，C组则短于D组；A组总的1：7腔溃疡发生率低于B组、C组及D组，B组则低于C组及D组，C组则低于D组，差异均有统计学意义（P均〈0．05）。结论：急性白血病化疗后应及早应用G—CSF，化疗后48h的应用效果相对更好。
Objective. To compare the effect of granulocyte colony-stimulating factor（G-CSF）at different application time after chemotherapy on patients with acute leukemia. Methods. A total of 80 patients with acute leukemia who were treated with G-CSF in our hospital from September 2010 to July 2013 were selected as research object. Based on the application time of G-CSF, they were divided into group A （application at 48 h after chemotherapy group） （n=20）, group B [-application with ANC （1.0-1.4）×10^9/ L] （n=20）, group C [application with ANC（0. 5-0. 9）×10^9/L] （n=20） and group D（application with ANC〈0.5×10^9/L）（n=20） . The time when ANC reached ≥ 1.5 ×10^9/L, application time of G-CSF and dental ulcer rate of two groups were compared. Results. The time when ANC reached ≥ 1.5×10^9/L, application time of G-CSF were as follows., group A〈group B〈group〈group D （all P〈0.05）. Conclusions.The patients with acute leukemia should be treated with G-CSF as soon as possible, and the application effect at 48 h after chemotherapy is relatively better.
出处
《海南医学院学报》
CAS
2014年第6期789-791,共3页
Journal of Hainan Medical University
基金
安康市科学技术研究发展计划立项(12AK02-19)~~
