摘要
目的：观察甲钴胺防治长春新碱神经毒性的近期疗效。方法：入选54例患者随机分为A、B两组,两组化疗方案均为含长春新碱1 mg/m2的化疗方案,21 d为1周期。A组（试验组）采用甲钴胺＋化疗,B组（对照组）单用化疗。A组在用长春新碱之前口服甲钴胺片0.5 mg/次,每日3次,第1~7 d,所有患者完成4周期化疗后评价疗效。结果：可评价病例54例,A组28例,发生神经毒性1级4例、2级2例、3级1例,总发生率25.0%。B组26例,发生神经毒性1级9例、2级4例、3级4例,总发生率65.4%。两组比较,差异有统计学意义（P〈0.05）。结论：甲钴胺能降低长春新碱神经毒性的发生率,值得临床推广应用。
Objective： To observe the short-term curative effect of methylcobalamin in preventing and treating vincristine-induced nerve toxicity. Methods： 54 patients were divided into two groups at random. Both the groups were given the same chemical treatment project of vincristine（ 1. 4 mg / m2）,with a treatment period of 21 days. The patients in Group A（ experiment group） were given methylcobalamin in addition to chemical treatment of vincristine and those in Group B（ control group） were given chemical treatment of vincristine only. The patients in Group A took oral methylcobalamin tablet（ 0. 5 mg / once,three times a day） for first 7 days before taking vincristine in every treatment period. The curative effect assessment was given to all the patients in both the groups by the end of the four treatment periods. Results： Of 54 cases evaluated（ 28 in Group A,26 in Group B）,7 cases of nerve toxicity occurred in Group A（ Grade Ⅰ 4,Grade Ⅱ 2,Grade Ⅲ 1）,with a total occurrence of 25. 0 %; 17 cases of nerve toxicity occurred in Group B,with a total occurrence rate of 65. 4 %. There was obvious difference between the two groups（ P 0. 05）. Conclusion： Methylcobalamin can reduce the development of the nerve toxicity induced by vincristine and can be widely applied to clinical practice.
出处
《包头医学院学报》
CAS
2014年第2期53-54,共2页
Journal of Baotou Medical College
关键词
甲钴胺
长春新碱
神经毒性
Methylcobalamin
Vincristine
Nerve toxicity
