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Nrf2通路的中枢神经保护作用研究概况 被引量：3

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摘要 中枢神经系统因为含有丰富的不饱和脂肪酸,所以对氧化应激以及脂质过氧化很敏感.寻找有效对抗自由基的药物,保持细胞的氧化还原活性显得尤为重要.以往人们利用外源性还原物质进行治疗,但是并没有达到理想效果,所以研究者转而研究内源性抗氧化机制.Nrf2是近年来新发现的一种核转录因子,在调节细胞抗氧化应激反应中起重要作用,Nrf2—旦被激活,就与ARE结合,从而启动一系列的基因来对抗氧化应激.研究Nrf2的神经保护作用,将为神经系统疾病的防治打开新思路[1].本文将近年来Nrf2通路的中枢神经保护作用研究作一综述,归纳如下.
作者 李好文 邓家刚
机构地区 广西中医药大学
出处 《广西中医药大学学报》 2014年第1期114-116,共3页 Journal of Guangxi University Of Chinese Medicine
基金 广西科技基础条件平台建设专项资金项目(K32920)
关键词 NRF2 神经保护 氧化应激 综述
分类号 R741.02 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献25

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二级参考文献40

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共引文献13

同被引文献27

  • 1李煌元,石年.Keap1-Nrf2/ARE通路在分子毒理学中的研究进展[J].国外医学（卫生学分册）,2006,33(3):129-135. 被引量：11
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引证文献3

二级引证文献20

广西中医药大学学报
2014年 第1期

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