摘要
目的观察单唾液酸四己糖神经节苷脂(GM1)联合小剂量阿司匹林治疗急性脑梗死的疗效和安全性。方法将入选急性脑梗死病例70例随机分为两组:(1)治疗组(35例),GM1 100 mg/d,静脉滴注,联合口服阿司匹林100 mg/d;(2)对照组(35例),复方丹参注射液20ml/d,静脉滴注。两组疗程均为14 d,评定指标包括治疗前及治疗14 d后脑梗死的神经功能缺损改善程度,总体改善率。结果治疗组和对照组临床疗效显效率分别为57.14%(20/35)与34.29%(12/35),总有效率分别为94.3%(33/35)与71.43%(25/35);两组总体有效率比较差异有显著统计学意义(P<0.01)。治疗前两组神经功能残缺积分比较差异无统计学意义(P>0.05)。治疗14 d后,两组神经功能缺损积分比较差异有显著统计学意义(P<0.01)。结论 GM1联合小剂量阿司匹林治疗急性脑梗死患者具有良好的中枢神经保护作用,其疗效明确,可大大改善脑梗死患者的神经功能缺损。
Objective To observe the clinical effect and safety of Monosialotetrahexosyl ganglioside（GM1） combined with Aspirin in the treatment of acute cerebral infarctions. Methods Seventy patients with acute cerebral infarctions were randomly divided into two groups：（1） the observation group（35 cases）,GM1 100mg/d for intravenous drip combined with oral Aspirin 100 mg/d;（2） the control group（35 cases）,compound Danshen injection 20ml/d for intravenous drip.The treatment lasted 14 d,the evaluating index including the recovery of neurological function deficit before and 14 d after treatment and overall improvement rate. Results The clinical effective rate of the observation group was 57.14%（20/35）,of the control group was 34.29%（12/35）,the total effective rate were 94.3%（33/35） and 71.4%（25/33） respectively.The difference of the total effective rate between the two groups was of statistical significance（P0.01）.The difference of nerve function incomplete integral before treatment in two groups showed no statistical significance（P0.05）,the difference of that at 14 d after treatment has statistical significance（P0.01）. Conclusion GM1 combined with small dose Aspirin is very effective in treatment of acute cerebral infarctions and has good central nervous protective effects,can significant improve neurological deficit in patients with cerebral infarction.
出处
《临床军医杂志》
CAS
2012年第6期1445-1447,共3页
Clinical Journal of Medical Officers
