摘要
目的：探讨对吗替麦考酚酯进行治疗药物监测的临床必要性.方法：采用HPLC方法测定血浆中麦考酚酸的谷浓度和峰浓度,对2012 年10 – 12 月期间83 例肾移植患者血浆麦考酚酸浓度进行分析.结果：患者血浆麦考酚酸谷浓度在0.34 ～ 3.99 μg·mL-1范围内的共46例次,血浆麦考酚酸峰浓度在0.91～12.78 μg·mL-1范围内的有37例次.在固定给药剂量下,麦考酚酸血药浓度的个体差异较大.结论：对吗替麦考酚酯进行治疗药物监测具有重要的临床价值.
Objective： To investigate the clinical necessity of therapeutic drug monitoring （TDM） of mycophenolatemofetil. Methods： The peak and trough concentrations of mycophenolic acid in plasma were determined by high performanceliquid chromatography （HPLC）. Plasma concentrations of mycophenolic acid in 83 cases of renal transplant recipients collected fromOctober to December in 2012 were analyzed. Results： The valley concentrations of mycophenolic acid in 46 patients were withinthe range from 0.34 μg·mL-1 to 3.99 μg·mL-1. The peak concentrations of mycophenolic acid in 37 cases were within the range from0.91 μg·mL-1 to 12.78 μg·mL-1. The concentrations of mycophenolic acid varied greatly with a fixed-dosage. Conclusion： There isa definite clinical value for therapeutic drug monitoring of mycophenolate mofetil.
出处
《中国药物应用与监测》
CAS
2014年第1期5-8,共4页
Chinese Journal of Drug Application and Monitoring
