摘要
目的研究三乙酰乌头碱(AAC)的镇痛作用及镇痛机制。方法通过醋酸扭体实验观察AAC的镇痛作用及盐酸吗啡(Mor)和氯胺酮注射液(KET)阈下镇痛剂量对AAC镇痛作用的影响,明确AAC的镇痛效果,初步探讨其作用机制。结果 AAC(0.06、0.03 mg·kg-1)对冰醋酸致小鼠扭体反应有明显抑制作用(P<0.05);阈下剂量AAC分别与阈下剂量Mor和KET合用对冰醋酸致小鼠扭体反应均有明显抑制作用(P<0.05)。结论 AAC与Mor或KET有协同镇痛作用,其作用机制可能与NMDA受体或内源性阿片肽有关。
Objective To investigate the analgesic effect and the possible mechanism of 3 - Acetyl aconitine （AAC）. Methods The analgesic effect of AAC was observed using acetic acid writhing test, associated tested by the subthreshold doses of morphine hydrochloride （Mor） ,ketamine injection （KET to investigate analgesic synergy between the analgesia）. Results The writhing in mice induced by acetic acid was inhibited by 0.06 mg · kg- 1 and 0.03 mg · kg- 1 of AAC significantly （P 〈 0.05 ）, and the analgesic effect showed a dose - dependent manner. The subthreshold doses of analgesic Mor and MET had an obvious synergy analgesic effect with AAC （P 〈 0.05 ）. Conclusion 3 - Acetyl aconitine combained Mor or KET has a synergic significant analgesic effect, and its mechanism may be associated with NMDA receptors or endogenous opioid peptides.
出处
《宁夏医学杂志》
CAS
2014年第5期388-390,共3页
Ningxia Medical Journal
关键词
三乙酰乌头碱
镇痛
吗啡
氯胺酮
3 - Acetyl aconitine
Analgesic
Morphine
Ketamine
