摘要
[目的]探讨肝动脉化疗栓塞(TACE)联合超声造影引导下射频消融(RFA)治疗原发性大肝癌的临床疗效。[方法]对48例大肝癌患者采用TACE联合超声造影引导下RFA治疗,对其治疗前后肿瘤最大直径、总胆红素(TBIL)、谷丙转氨酶(ALT)、甲胎蛋白(AFP)、肝功能分级进行对比分析。[结果]术后除1例发生肝脏衰竭,积极治疗抢救无效死亡外,余47例均手术成功。与术前比较,47例术后AFP、肿瘤最大径差异有统计学意义(P<0.05),TBIL、ALT差异无统计学意义(P>0.05)。半年、1年生存率分别为82.9%(39/47)和61.7%(29/47),中位生存期11.5个月,平均生存期13.8个月。[结论]TACE联合超声造影引导下行RFA治疗原发性大肝癌疗效确切。
[Objective]To evaluate the effect of transcatheter arterial chemoembolization （TACE） com- bined with contrast-enhanced sonography guided radiofrequency ablation（RFA） in treating massive primary hepatocellular carcinomas, [Methods]Forty-eight patients with massive primary hepatocellular carcinoma were treated with TACE combined with contrast-enhanced sonography guided RFA. The clinical data of these patients, collected in our center from June 2006 to July 2010, were retrospectively analyzed. [Results] The post-operation clinical data of 48 patients show lower in alpha fetoprotein（AFP） and smaller diameters of active tumor than pre-operation, the differences showed statistical significance（P〈0. 05）. However, there was no statistical significance of the data between pre-operation and post-operation in total bilirubin （TBIL）,glutamic-pyruvic transaminase （ALT）. Half-year survival rate and one-year survival rate were 82.9% （39/47）respectively and 61.7% （29/47）. The median survival time was 11.5 months and the mean survival time was 13.8 months. These data showed advantage treatment effect in massive primary hepato- cellular carcinomas. [Conclusion]TACE combined with contrast-enhanced sonography guided RFA is an ef- fective and advantage treatment for massive primary hepatocellular carcinomas.
出处
《临床消化病杂志》
2014年第2期96-99,共4页
Chinese Journal of Clinical Gastroenterology
关键词
原发大肝癌
肝动脉化疗栓塞
超声造影
射频消融
massive primary hepatocellular carcinomas, transcatheter arterial chemoembolization,con-trast-enhanced sonography, radiofrequency ablation
