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肺动脉平滑肌细胞增殖的分子机制及干预的研究进展 被引量：3

Advances in research on molecular mechanisms for the proliferation of pulmonary artery smooth muscle cells and their intervention
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摘要 肺动脉高压是一种常见的临床综合征。肺动脉平滑肌细胞的过度增殖是构成肺血管重塑的主要病理基础,而肺血管重塑是导致肺动脉高压发生的关键病理变化。本文总结了促进肺动脉平滑肌细胞增殖的分子信号通路的研究进展,并介绍了目前抑制肺动脉平滑肌细胞增殖靶向治疗的现状及研究进展。 Pulmonary artery hypertension （PAH） is a common clinical syndrome. The over-proliferation of pulmonary artcrial smooth muscle cells （PASMCs） is a hallmark of pulmonary vascular remodeling which is a critical and fundamental pathogenesis in the development of a variety of pulmonary artery hypertension. Here, wc review the advances in studies on signaling transduction pathways mediating the proliferation of PASMCs and also introduce the existing approaches in inhibiting their proliferation and relevant research advances.
作者 李满祥 卢家美
机构地区 西安交通大学医学院第二附属医院呼吸病研究室 西安交通大学医学院第二附属医院呼吸内科
出处 《西安交通大学学报（医学版）》 CAS CSCD 北大核心 2014年第3期285-289,共5页 Journal of Xi’an Jiaotong University（Medical Sciences）
基金 国家自然科学基金资助项目(No.81070045) 卫生部部属(管)医院临床学科重点项目(No.111) 教育部高等学校博士学科点专项科研基金(No.20100201110050)~~
关键词 肺动脉高压 肺动脉平滑肌细胞 增殖 分子机制 干预 pulmonary hypertension pulmonary artery smooth muscle cell proliferation molecular mecha-nism ~ intervention
分类号 R563 [医药卫生—呼吸系统]
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参考文献42

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二级参考文献15

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共引文献1

同被引文献32

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引证文献3

二级引证文献22

西安交通大学学报（医学版）
2014年 第3期

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